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Revista Brasileira de Coloproctologia

On-line version ISSN 0101-9880

Abstract

CESAR, Maria Auxiliadora Prolungatti et al. The role of nifedipine 0,2% in cronic anal fissure-manometric study pre and post treatment. Rev bras. colo-proctol. [online]. 2007, vol.27, n.2, pp.185-189. ISSN 0101-9880.  http://dx.doi.org/10.1590/S0101-98802007000200009.

In the treatment of the anal fissure, calcium channel blockers are among the new drugs which have been used. The objective of this research was the manometric evaluation of patients with chronic anal fissure after topic treatment with 0.2% nifedipine and correlation with the healing and pain. This is a prospective study of patients from Coloproctology Clinic of the University of Taubaté Hospital. The patients had been submitted to a manometric examination before and after 30 days of the use of topic 0.2% nifedipine gel three times a day in the anus and anal edge. For the statistics analysis Mann-Whitney test was applied to a significance of p= 0,05. Ten patients did not exihibit manometric alteration associated with nifedipina treatment, however 50% of them reported improvement of the symptoms and 40% depicted healing of the fissure. The results demonstrated that nifedipine was effective and safe for anal fissure treatment and considering the functional point of view it did not cause injuries as well. The manometric evaluation did not demonstrate alterations in the anal pressure; however, it was observed that 50% of the patients had improvement in pain and 40% in healing.

Keywords : manometry; fissure; nifedipine; anal canal.

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