SciELO - Scientific Electronic Library Online

vol.56 issue1Effect of formalin and Bouin fixation upon the mare's endometrial biopsies embedded in plastic resin author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Arquivo Brasileiro de Medicina Veterinária e Zootecnia

Print version ISSN 0102-0935On-line version ISSN 1678-4162


NASCIMENTO, R.A.P. et al. Evaluation of vaccines against Clostridium novyi type B. Arq. Bras. Med. Vet. Zootec. [online]. 2004, vol.56, n.1, pp.1-6. ISSN 0102-0935.

The antibody response to the Clostridium novyi type B alfa toxin component of 13 commercial vaccines (T1 to T13) and a standard toxoid was evaluated by the serum neutralization test with rabbit and cattle sera and by direct challenge of vaccinated guinea pig. T1 and T10 induced titles of C. novyi type B alfa antitoxin in rabbits, superior to the recommended minimum title of 3.5 IU/ml, namely of 8 and 12 IU/ml, respectively. T2 and T5 induced titles of 2 and 3 IU/ml, respectively. These, plus T1 and T10, were also the only vaccines which produced detectable antitoxin in bovine sera. T1, T2, T5 and T10, plus T11, were able to protect all the vaccinated guinea pigs at the challenge. Most of C. novyi type B vaccines in Brazil was unable to induce the minimum antibody response recommended for approval of the product.

Keywords : vaccine; toxin; Clostridium novyi type B; infectious necrotic hepatitis; clostridiosis.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License