SciELO - Scientific Electronic Library Online

vol.63 issue6Nitric oxide, GSTP-1 and p53: what's the role of these biomarkers in dog´s prostate lesions?Hematological and clinical profiles of mice submitted to experimental poisoning with Tityus fasciolatus venom author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand



Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Arquivo Brasileiro de Medicina Veterinária e Zootecnia

On-line version ISSN 1678-4162


GAMBA, C.O. et al. Tubulopapillary carcinoma of the mammary gland in a maned wolf (Chrysocyon brachyurus): histopathological and immunophenotypical analysis. Arq. Bras. Med. Vet. Zootec. [online]. 2011, vol.63, n.6, pp.1377-1381. ISSN 1678-4162.

A maned female wolf (Chrysocyon brachyurus) showed nodules in the inguinal and left abdominal cranial mammary glands. The mammary gland was surgically excised, and microscopic analysis revealed epithelial cell proliferation in a tubular and papillary pattern; delicate fibrovascular stalks presenting numerous layers of moderately pleomorfic epithelial cells were observed. This histologic appearance was compatible with a diagnosis of mammary tubulopapillary carcinoma. The immunohistochemical profile revealed nuclear positivity for estrogen (70%) and progesterone (at least 90% of the neoplastic cells). The myoepithelium-associated with neoplastic cells lacked integrity, as evidenced by failed smooth muscle alpha actin reactivity in microinvasive areas. A low proliferation index was observed (3.4%). To the authors' knowledge, the present case represents the first finding of female tubulopapillary carcinoma in a mammary gland in this species.

Keywords : Chrysocyon brachyurus; female maned wolf; immunohistochemistry; mammary gland; tubulopapillary carcinoma.

        · abstract in Portuguese     · text in English     · English ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License