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Arquivo Brasileiro de Medicina Veterinária e Zootecnia

Print version ISSN 0102-0935

Abstract

LEAL, L.M. et al. The use of paca peritoneum preserved in supersaturated sugar solution 300% or glycerine 98% implanted in the abdominal wall of rats. Arq. Bras. Med. Vet. Zootec. [online]. 2014, vol.66, n.5, pp.1383-1391. ISSN 0102-0935.  http://dx.doi.org/10.1590/1678-6703.

In the search for alternative biological material to perform implants, this study aimed to compare the implantation of paca peritoneum, a new biomaterial option, preserved in supersaturated sugar solution 300% and preserved in glycerin 98% in the abdominal wall of Wistar rats. A total of 60 male rats from the Wistar strain weighing between 150 and 200 grams were housed into three different experimental groups: control group (GI), peritoneum preserved in supersaturated sugar solution 300% group (GII) and peritoneum preserved in glycerin 98% group (GIII), with 20 animals each. The GII and GIII received the paca peritoneum graft preserved in sugar solution 300% and glycerin 98%, respectively and group GI did not receive any membrane. Five rats from each group were euthanized at four different times: seven, 15, 30 and 60 days post-surgery for macroscopic and microscopic evaluations in graft-native tissue interface. Despite the adverse reactions observed in 57.5% of GII and GIII, there was good healing of the membrane in 95% of the animals in these groups. Upon histological examination there was a large presence of inflammatory infiltrates in the initial periods (seven and 15 days) and a large presence of connective tissue in the final stages (30 and 60). It was concluded that the paca peritoneum as biological membrane preserved as presented in this study can be used safely in the abdominal wall of rats, the preservation in supersaturated sugar solution 300% allowed better flexibility during surgery.

Keywords : healing; surgery; graft; biological membrane; Cuniculus paca.

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