SciELO - Scientific Electronic Library Online

vol.69 issue5Escherichia coli and Salmonella ser. Saintpaul natural co-infection in a free-living ruddy ground dove (Columbina talpacoti): a case reportKartogenin associated to micro of the subchondral bone in the joint cartilage repair in horses author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Arquivo Brasileiro de Medicina Veterinária e Zootecnia

On-line version ISSN 1678-4162


RODRIGUES, D.F. et al. Treatment of excisional wound in rabbits with barbatiman extracts associated with autologous bone marrow mononuclear cells. Arq. Bras. Med. Vet. Zootec. [online]. 2017, vol.69, n.5, pp.1243-1250. ISSN 1678-4162.

This study aimed to evaluate the healing process of wounds of rabbits in response to treatment with barbatiman extract (S. adstringens) associated with autologous mononuclear bone marrow cells (BM-MNC). We used 20 rabbits, divided into four groups: B, 10% barbatiman extract with 9.48% of total tannins; CB, BM-MNC with barbatiman extract; CS, BM-MNC with NaCl 0.9% solution; S, NaCl 0.9% solution. Clinical evaluation was performed by observing the presence of crust, redness, discharge, bleeding, re-epithelialization, the wound area and healing time in days. In the third, seventh, 14th and 21st postoperative days wounds were biopsied for microscopic evaluation of inflammation and repair process indicators, especially collagen, in picrosirius staining, and cell proliferation, in AgNOR staining. There was a greater deposition of collagen fibers in groups B and CB (p=0.00003) on the seventh day and formation of thicker crusts, and more organized collagen fibers on the 21st day in these groups. In conclusion, in the initial phase of healing, barbatiman extract stimulates the production of collagen fibers and promotes the formation of more exuberant crusts on the wounds and remodeling phase favors the orientation of collagen fibers, but when combined with BMMC does not stimulate wound healing in rabbits.

Keywords : AgNOR; cell therapy; collagen; wound healing; Stryphnodendron adstringens.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf )