Factors associated with treatment for latent tuberculosis in persons living with HIV/AIDS

Aquino, Daniela Silva de; Moura, Líbia Cristina Rocha Vilela; Maruza, Magda; Silva, Adriana Paula da; Ximenes, Ricardo Arraes de Alencar; Lacerda, Heloísa Ramos; Miranda Filho, Demócrito de Barros; Albuquerque, Maria de Fátima Pessoa Militão de

doi:10.1590/0102-311X00154614

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Article • Cad. Saúde Pública 31 (12) • Dec 2015 • https://doi.org/10.1590/0102-311X00154614 copy

Factors associated with treatment for latent tuberculosis in persons living with HIV/AIDS

Fatores associados ao tratamento da tuberculose latente em pessoas vivendo com HIV/AIDS

Factores asociados al tratamiento de la tuberculosis latente en personas viviendo con VIH/SIDA

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

The aim was to identify factors associated with non-initiation of prophylactic treatment of latent tuberculosis infection (LTB_i) in persons living with HIV/AIDS (PLWA), based on a prospective cohort study of PLWA ≥ 18 years of age in two referral services for HIV/AIDS. Of the 232 patients eligible for treatment of LTB_i, 69.8% initiated treatment. Following multivariate logistic regression analysis, only treatment in one of the two referral services was associated with non-initiation of treatment for LTB_i (p < 0.001). TB incidence in the cohort was 0.6/100 person-years. TB incidence in patients that initiated treatment of LTB_i was 0.4/100 person-years, compared to 1.2/100 person-years in those that did not initiate treatment, but the difference was not statistically significant. The study’s most interesting finding was that the main factor associated with the likelihood of treatment for LTB_i was the health service where the patient was treated.

Tubeculosis; HIV; Isoniazid

	LTBi treatment				p-value
	Yes (n = 162)	No (n = 70)	OR	95%CI	p-value
Sex			0.9100	0.5170-1.6020	0.744
Female	68 (68.7%)	31 (31.3%)
Male	94 (70.7%)	39 (29.3%)
Age (years)			0.8351	0.4754-1.4668	0.531
≥ 40	83 (68.0%)	39 (32.0%)
< 40	79 (71.8%)	31 (28.2%)
Live alone or not			1.3888	0.6858-2.8127	0.362
Does not live alone	135 (71.4%)	54 (28.6%)
Lives alone	27 (64.3%)	15 (35.7%)
Literacy			0.2508	0.5635-1.116	0.070
Yes	145 (68.1%)	68 (31.9%)
No	17 (89.5%)	2 (10.5%)
Smoker			1.096	0.6016-1.9971	0.764
Never smoked & ex-smoker	112 (70.4%)	47 (29.6%)
Smoker	50 (68.5%)	23 (31.5%)
Alcohol use			1.6213	0.9217-2.8518	0.094
Does not drink	98 (74.2%)	34 (25.8%)
Drinks	64 (64.0%)	36 (36.0%)
Use of illicit drugs			1.980	1.0856-3.6124	0.026
No	123 (74.1%)	43 (25.9%)
Yes	39 (59.1%)	27 (40.9%)
Use of ART			0.9265	0.4528-1.8956	0.835
Yes	130 (69.5%)	57 (30.5%)
No	32 (71.1%)	13 (28.9%)
Contact with tuberculosis			1.1008	0.6112-1.9824	0.749
No	107 (70.4%)	45 (29.6%)
Yes	54 (68.4%)	25 (31.6%)
CD4 cell count (cel/mm³)			1.2540	0.3642-4.3180	0.720
≥ 200	153 (71.5%)	61 (28.5%)
< 200	8 (66.7%)	4 (33.3%)
BMI (kg/m²)			0.9914	0.2488-3.9509	0.990
≥ 18.5	155 (69.8%)	67 (30.2%)
< 18.5	7 (70.0%)	3 (30.0%)
Health service			6.2206	3.3493-11.5536	0.000
Service 1	132 (82.0%)	29 (18.0%)
Service 2	30 (42.3%)	41 (57.7%)

Variables	Treatment of LTB_i
Variables	OR (95%CI)	p-value
Use of illicit drugs
No	1.00
Yes	1.80 (0.93-3.48)	0.077
Health service
Service 1	1.00
Service 2	6.04 (3.23-11.27)	0.000

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[1] Correspondence
D. S. Aquino. Rua Bartolomeu de Gusmão 186, apto. 1104, Recife, PE 50610-190, Brasil. aquino.daniela@hotmail.com