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Cadernos de Saúde Pública

versão impressa ISSN 0102-311Xversão On-line ISSN 1678-4464

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DABES, Clarice Gomes e Souza; ALMEIDA, Alessandra Maciel  e  ACURCIO, Francisco de Assis. Non-adherence to biological therapy in patients with rheumatic diseases in the Brazilian Unified National Health System in Minas Gerais State, Brazil. Cad. Saúde Pública [online]. 2015, vol.31, n.12, pp.2599-2609. ISSN 0102-311X.  http://dx.doi.org/10.1590/0102-311X00169514.

This study examined non-adherence to biological therapy with adalimumab and etanercept and associated factors in patients with rheumatic diseases treated under the Brazilian Unified National Health System in Minas Gerais State, Brazil. A non-concurrent cohort study was performed from pharmacy records of adult patients that had recently initiated treatment. Patient non-adherence was measured by proportion of days covered (PDC), and non-adherent patients were defined as PDC < 0.8. A total of 1,150 patients were included, with the following breakdown: 64.3% rheumatoid arthritis, 8.5% psoriatic arthritis , and 27.2% ankylosing spondylitis. In total, 33.5% of patients were non-adherent. Factors such as younger age (19-39 years), female gender, diagnosis of rheumatoid arthritis , and initial treatment with etanercept were associated with low adherence. The results indicate a high prevalence of non-adherence, which can lead to worse health outcomes and increase healthcare use and costs.

Palavras-chave : Medication Adherence; Biological Therapy; Rheumatic Diseases.

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