Fishes |
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Danio rerio
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Embryos |
Change in mating behavior 5757 () Volkova K, Reyhanian NC, Porseryd T, Hallgren S, Dinnétz P, Porsch-Hällström I. Developmental exposure of zebrafish (Danio rerio) to 17α-ethinylestradiol affects non-reproductive behavior and fertility as adults, and increases anxiety in unexposed progeny. Horm Behav 2015; 73:30-8.; Induction of vitellogenin synthesis in males; Anomalies and mortality in embryos 5858 () Soares J, Coimbra AM, Reis-Henriques MA, Monteiro NM, Vieira MN, Oliveira JM, et al. Disruption of zebrafish (Danio rerio) embryonic development after full life-cycle parental exposure to low levels of ethinylestradiol. Aquat Toxicol 2009; 95:330-8.
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Adult males and females |
Histopathological changes in females 5959 () Silva P, Rocha MJ, Cruzeiro C, Malhão F, Reis B, Urbatzka R, et al. Testing the effects of ethinylestradiol and of an environmentally relevant mixture of xenoestrogens as found in the Douro River (Portugal) on the maturation of fish gonads: a stereological study using the zebrafish (Danio rerio) as model. Aquat Toxicol 2012; 124-125:1-10.
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Adult males |
Induction of vitellogenin synthesis and behavior changes 6060 () Reyhanian N, Volkova K, Hallgren S, Bollner T, Olsson PE, Olsén H, et al. 17α-ethinyl estradiol affects anxiety and shoaling behavior in adult male zebra fish (Danio rerio). Aquat Toxicol 2011; 105:41-8.
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Different stages |
Indução da síntese de viteloginina; Atraso e redução da desova; Redução das taxas de fertilização 6161 () Segner H, Caroll K, Fenske M, Janssen CR, Maack G, Pascoe D, et al. Identification of endocrine-disrupting effects in aquatic vertebrates and invertebrates: report from the European IDEA project. Ecotoxicol Environ Saf 2003; 54:302-14.
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Oryzias latipes
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Embryos |
Significant reduction in fertilization rate 6262 () Bhandari RK, Vom Saal FS, Tillitt DE. Transgenerational effects from early developmental exposures to bisphenol A or 17α-ethinylestradiol in medaka, Oryzias latipes. Sci Rep 2015; 5:9303.
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Adult males |
Induction of vitellogenin synthesis and feminization 6363 () Hirakawa I, Miyagawa S, Katsu Y, Kagami Y, Tatarazako N, Kobayashi T, et al. Gene expression profiles in the test is associated with testis-ova in adult Japanese medaka (Oryzias latipes) exposed to 17α-ethinylestradiol. Chemosphere 2012; 87:668-74.
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One day after birth |
Significant change in sex ratio (more females) and hermaphroditism 6464 () Metcalfe CD, Metcalfe TL, Kiparissis Y, Koenig BG, Khan C, Hughes RJ, et al. Estrogenic potency of chemicals detected in sewage treatment plant effluents as determined by in vivo assays with Japanese medaka (Oryzias latipes). Environ Toxicol Chem 2001; 20:297-308.
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Oryzias melastigma
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Adult males and females |
Changes in mating behavior and inhibition of spawning 6565 () Lee PY, Lin CY, Chen TH. Environmentally relevant exposure of 17α-ethinylestradiol impairs spawning and reproductive behavior in the brackish medaka Oryzias melastigma. Mar Pollut Bull 2014; 85:338-43.
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Pimephales promelas
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Embryos |
Decrease in body size and induction of vitellogenin synthesis 88 () Johns SM, Denslow ND, Kane MD, Watanabe KH, Orlando EF, Sepúlveda MS. Effects of estrogens and antiestrogens on gene expression of fathead minnow (Pimephales promelas) early life stages. Environ Toxicol 2011; 26:195-206.; Decrease in fertilization of eggs and feminization 6666 () Parrott JL, Blunt BR. Life-cycle exposure of fathead minnows (Pimephales promelas) to an ethinylestradiol concentration below 1 ng/L reduces egg fertilization success and demasculinizes males. Environ Toxicol 2005; 20:131-41.; Induction of vitellogenin synthesis; feminization; Significant inhibition of spermatogenesis 6767 () van Aerle R, Pounds N, Hutchinson TH, Maddix S, Tyler CR. Window of sensitivity for the estrogenic effects of ethinylestradiol in early life-stages of fathead minnow, Pimephales promelas. Ecotoxicology 2002; 11:423-34.
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Adult males |
Changes in reproductive behavior, reduction in hormone levels, and secondary sexual characteristics 6868 () Salierno JD, Kane AS. 17alpha-ethinylestradiol alters reproductive behaviors, circulating hormones, and sexual morphology in male fathead minnows (Pimephales promelas). Environ Toxicol Chem 2009; 28:953-61.
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Betta splendens
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Young and adult males and females |
Changes in mating behavior 6969 () Dzieweczynski TL, Campbell BA, Marks JM, Logan B. Acute exposure to 17α-ethinylestradiol alters boldness behavioral syndrome in female Siamese fighting fish. Horm Behav 2013; 66:577-84.
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Pomatoschistus minutus
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Adult males |
Induction of vitellogenin synthesis and zona radiata protein 1111 () Humble JL, Hands E, Saaristo M, Lindström K, Lehtonen KK, Diaz de Cerio O, et al. Characterization of genes transcriptionally upregulated in the liver of sand goby (Pomatoschistus minutus) by 17α-ethinyloestradiol: identification of distinct vitellogenin and zona radiata protein transcripts. Chemosphere 2013; 90:2722-9.
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Gasterosteus aculeatus
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Adult males |
Changes in mating behavior 6363 () Hirakawa I, Miyagawa S, Katsu Y, Kagami Y, Tatarazako N, Kobayashi T, et al. Gene expression profiles in the test is associated with testis-ova in adult Japanese medaka (Oryzias latipes) exposed to 17α-ethinylestradiol. Chemosphere 2012; 87:668-74.
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Gobiocypris rarus
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Adult males and females |
Induction of vitellogenin synthesis in both sexes, alterations in liver and kidneys, feminization 7070 () Zha J, Wang Z, Wang N, Ingersoll C. Histological alternation and vitellogenin induction in adult rare minnow (Gobiocypris rarus) after exposure to ethynylestradiol and nonylphenol. Chemosphere 2007; 66:488-95.
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Amphibians |
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Xenopus laevis
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Adult males |
Induction of vitellogenin synthesis and hepatic alterations 7171 () Garmshausen J, Kloas W, Hoffmann F. 17α-ethinylestradiol can disrupt hemoglobin catabolism in amphibians. Comp Biochem Physiol C Toxicol Pharmacol 2015; 171:34-40.; Changes in mating behavior 7272 () Hoffmann F, Kloas W. Estrogens can disrupt amphibian mating behavior. PLoS One 2012; 7:e32097.; Significant behavior changes 7373 () Hoffmann F, Kloas W. The antiestrogens tamoxifen and fulvestrant abolish estrogenic impacts of 17α-ethinylestradiol on male calling behavior of Xenopus laevis. PLoS One 2012; 7:e44715.
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Hyalella azteca
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4 to 6 weeks after gametogenesis |
Growth reduction in males 6161 () Segner H, Caroll K, Fenske M, Janssen CR, Maack G, Pascoe D, et al. Identification of endocrine-disrupting effects in aquatic vertebrates and invertebrates: report from the European IDEA project. Ecotoxicol Environ Saf 2003; 54:302-14.
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Gammarus pulex
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Different stages |
Significant increase in mean population size; change in adult sex ratio (2:1 in favor of females) 7474 () Watts MM, Pascoe D, Carroll K. Population responses of the freshwater amphipod Gammarus pulex (L.) to an environmental estrogen, 17alpha-ethinylestradiol. Environ Toxicol Chem 2002; 21:445-50.
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Crustaceans |
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Daphnia magna
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Larvae |
Decrease in number of progeny per female 7575 () Luna TO, Plautz SC, Salice CJ. Chronic effects of 17α-ethinylestradiol, fluoxetine, and the mixture on individual and population-level end points in Daphnia magna. Arch Environ Contam Toxicol 2015; 68:603-11.
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Ceriodaphnia reticulata
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Larvae |
Increased mortality in newborns 7676 () Jaser W, Severin GF, Jütting U, Jüttner I, Schramm KW, Kettrup A. Effects of 17alpha-ethinylestradiol on the reproduction of the cladoceran species Ceriodaphnia reticulata and Sida crystallina. Environ Int 2003; 28:633-8.
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Sida crystallina
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Larvae |
Shorter juvenile phase 7676 () Jaser W, Severin GF, Jütting U, Jüttner I, Schramm KW, Kettrup A. Effects of 17alpha-ethinylestradiol on the reproduction of the cladoceran species Ceriodaphnia reticulata and Sida crystallina. Environ Int 2003; 28:633-8.
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Mollusks |
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Lymnea stagnalis
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Ova |
Significant hatching delay; Deformations in developing snails; Growth reduction in progeny 6161 () Segner H, Caroll K, Fenske M, Janssen CR, Maack G, Pascoe D, et al. Identification of endocrine-disrupting effects in aquatic vertebrates and invertebrates: report from the European IDEA project. Ecotoxicol Environ Saf 2003; 54:302-14.
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Adult males and females |
Reproductive changes 7777 () Giusti A, Lagadic L, Barsi A, Thomé JP, Joaquim-Justo C, Ducrot V. Investigating apical adverse effects of four endocrine active substances in the freshwater gastropod Lymnaea stagnalis. Sci Total Environ 2014; 493:147-55.
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Porifera |
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Hydra vulgaris
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Adult males and females |
Significant reductions in number of oocytes (females) and sperm activity (males) 6161 () Segner H, Caroll K, Fenske M, Janssen CR, Maack G, Pascoe D, et al. Identification of endocrine-disrupting effects in aquatic vertebrates and invertebrates: report from the European IDEA project. Ecotoxicol Environ Saf 2003; 54:302-14.
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Echinoderms |
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Hemicentrotus pulcherrimus/Strongylocentrotus nudus
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Embryos and larvae |
Altered morphogenesis 7878 () Kiyomoto M, Kikuchi A, Morinaga S, Unuma T, Yokota Y. Exogastrulation and interference with the expression of major yolk protein by estrogens administered to sea urchins. Cell Biol Toxicol 2008; 24:611-20.
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