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Jornal de Pneumologia
On-line version ISSN 1678-4642
BOMBARDA, SIDNEY; SOARES JUNIOR, JOSÉ and TERRA FILHO, MÁRIO. Evaluation of glucose metabolism in active lung tuberculosis by positron-emission tomography (18F-FDG PET). J. Pneumologia [online]. 2002, vol.28, n.5, pp. 270-276. ISSN 1678-4642. http://dx.doi.org/10.1590/S0102-35862002000500005.
Current methods to evaluate lung tuberculosis include chest radiography and computed tomography. Nuclear medicine imaging techniques are performed after administration of specific radiopharmaceuticals that accumulate in the organs of interest. Alterations of glucose metabolism can be observed by positron-emission tomography, using 18F-fluorodeoxyglucose (18F-FDG PET). These findings are present in the neoplasms, but also in inflammatory and infectious diseases. Tuberculosis is a granulomatous disease caused by Mycobacterium tuberculosis , that uses glucose as an energy source. Purpose: The study of glucose metabolism in lung tuberculosis by PET and the comparison of this results to CT scan findings. Material and methods: Twenty patients with active lung tuberculosis were evaluated. The 18F-FDG PET and computed tomography were performed in all patients, after the diagnosis and until 30 days of treatment. Results of both methods were compared. Results: All patients showed 18F-FDG positive uptake. On the computed tomography, all patients showed signs compatible with tuberculosis. The sensitivity of both methods was of 100%. There was significant concordance between the two methods (K = 0.27). Conclusions: The study concludes that glucose metabolism is modified in lung tuberculosis. There was concordance in the anatomic changes observed on computed tomography.
Keywords : Tuberculosis; Glucose; Fluorodeoxyglucose; Emission-computed tomography; Computed tomography.