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Jornal de Pneumologia
On-line version ISSN 1678-4642
TEIXEIRA, Ricardo Henrique de Oliveira Braga et al. Alveolar hemorrhage associated with lupus nephritis. J. Pneumologia [online]. 2003, vol.29, n.6, pp. 401-404. ISSN 1678-4642. http://dx.doi.org/10.1590/S0102-35862003000600014.
Alveolar hemorrhage leading to respiratory failure is uncommon. Various etiologies have been reported, including systemic lupus erythematosus, which generally presents as pulmonary-renal syndrome. It is believed that the pathogenesis of microangiopathy is related to deposits of immune complexes that lead to activation of cellular apoptosis. The authors report two cases of alveolar hemorrhage and respiratory failure, both requiring mechanical ventilation. The two cases had opposite outcomes after pharmacological therapy. The presence of anti-glomerular basement membrane antibodies in one of the cases demonstrates the multiplicity of physiopathological mechanisms that may be involved. This multiplicity of mechanisms provides a possible explanation for the heterogeneous responses to the available treatments.
Keywords : Lupus erythematosus systemic [etiology]; Lupus nephritis [etiology]; Respiratory insufficiency [complications].