Vitamin D and its relation to bone mineral density in postmenopause women

250 women with mean age of 71.1 were evaluated. The serum levels of vitamin D considered sufficient were â‰¥ 30 ng/mL, insufficient between 20 and 30 ng/mL and deficient < 20 ng/mL. The bone mineral density was measured and considered osteopenia when T value total of lumbar spine or hip was between -1 and -2.5 and osteoporosis < 2.5. The patients with fractures accounted for 25.2%.

RESULTS:

There was no significant difference in the vitamin D (ng/mL) levels among the age groups (p = 0.25), the levels of fractures (p = 0.79) and the levels of BMD (p = 0.76).

CONCLUSION:

82% of the patients presented deficient and insufficient blood levels of vitamin D. Ours results showed any significant correlation between vitamin D levels and bone mineral density after adjusting for age.

Vitamin D; Osteoporosis ; Bone density ; Fractures, bone

Variable	Mean	SD	Median	Minimum	Maximum
Age (years)	71,1	10,3	71	45	98
Vitamin D	23,8	10,5	21,8	5,7	80,9
Spine BMD	-1,4	1,4	-1,5	-4,6	3,7
Femur BMD *	-1,3	1,2	-1,3	-5,4	2

Variable	Category	n	%
	45 to 49	4	1,6
	50 to 59	28	11,2
Age (years)	60 to 69	76	30,4
	70 to 79	89	35,6
	80 to 89	45	18,0
	90 to 99	8	3,2
Fracture	yes	63	25,2
Fracture	no	187	74,8
	≤ 20	94	37,6
Vitamin D (classification)	21 to 29	111	44,4
	≥ 30	45	18,0
BMD (classification)	normal	58	23,2
	osteopenia	114	45,6
		78	31,2

Subgroup	Category	n	Mean ± SD	p valueª
Fracture	yes	63	75,3 ± 11,5
Fracture	no	187	69,7 ± 9,5
	normal	58	68,4 ± 10,4
BMD (classification	osteopenia	114	69,6 ± 9,7	0,0001
	osteoporosis	78	75,3 ± 10,0
	deficiency	94	72,6 ± 10,5
Vitamin D (classification)	insufficient	111	111 69,7 ± 9,6	0,13
	sufficient	45	71,5 ± 11,3

Variable	Category	n	Median	Minimum	Maximum	p valueª
	45 to 59	32	21,7	14,1	56,9
Age (years)	60 to 69	76	22,2	9,7	64,7	0,25
Age (years)	70 to 79	89	20,8	9,0	80,9	0,25
	80 to 99	53	22,6	5,7	72,0
Fracture	yes	63	22,1	5,7	72,0	0,79
Fracture	no	187	21,6	6,2	80,9	0,79
	normal	58	21,2	9,3	64,7
BMD (classification)	osteopenia	114	21,9	9,0	52,4	0,76
	osteoporosis	78	22,2	5,7	80,9

		45 to 59 years old		60 to 69 years old		70 to 79 years old		80 to 99 years old
Variable	Category	n	%	n	%	n	%	n	%	p valueª
Fracture	yes	7	21,9	12	15,8	19	21,4	25	47,2	< 0,0001
	no	25	78,1	64	84,2	70	78,7	28	52,8	< 0,0001
	deficiency	10	31,3	26	34,2	39	43,8	19	35,9
Vitamin D (classification)	insufficient	16	50,0	36	47,4	40	44,9	19	35,9	0,22
sufficient	6	18,8	14	18,4	10	11,2	15	28,3
	normal	12	37,5	19	25,0	19	21,4	8	15,1
DMO (classification)	osteopenia	15	46,9	40	52,6	41	46,1	18	34,0	0,006
	osteoporosis	5	15.6	17	22,4	29	32,6	27	50,9

		With Fracture	Without Fracture
Variable	Category	n	%	n	%	p value ª
	45 to 59	7	11,1	25	13,4
Age (years)	60 to 69	12	19,1	64	34,2	< 0,0001
70 to 79	19	30,2	70	37,4		< 0,0001
	80 to 99	25	39,7	28	15,0
Vitamin D (classification)	deficiency	23	36,5	71	38,0
Vitamin D (classification)	insufficient	27	42,9	84	44,9	0,82
	sufficient	13	20,6	32	17,1
	normal	7	11,1	51	27,3
BMD (classification)	osteopenia	29	46,0	85	45,5	0,011
	osteoporosis	27	42,9	51	27,3

		Deficient	Insufficient
Variable	Category	n	%	n	%	n	%	p value ª
	45 to 59	10	10,6	16	14,4	6	13,3
Age (years)	60 to 69	26	27,7	36	32,4	14	31,1	0,22
70 to 79	39	41,5	40	37,4	10	22,2		0,22
	80 to 99	19	20,2	19	15,0	15	33,3
Fracture	yes	23	24,5	27	38,0	13	28,9	0,82
Fracture	no	71	75,5	84	44,9	32	71,1	0,82
	normal	25	26,6	22	17,1	11	24,4
BMD (classification)	osteopenia	39	41,5	55	27,3	20	44,4	0,77
	osteoporosis	30	31,9	34	45,5	14	31,1

		Normal	Osteopenia	Osteoporosis
Variável	Categoria	n	%	n	%	n	%	p value ª
	45 to 59	12	20,7	15	13,2	5	6,4
Age (years)	60 to 69	19	32,8	40	35,1	17	21,8	0,006
70 to 79	19	32,8	41	36,0	29	37,2		0,006
	80 to 99	8	13,8	18	15,8	27	34,6
Fracture	yes	7	12,1	29	25,4	27	34,6	0,011
Fracture	no	51	87,9	85	74,6	51	65,4	0,011
	deficiency	25	43,1	39	34,2	30	38,5
BMD (classification)	insufficient	22	37,9	55	48,3	34	43,6	0,77
	sufficient	11	19,0	20	17,5	14	18,0

Sociedade Brasileira de Ortopedia e Traumatologia Al. Lorena, 427 14º andar, 01424-000 São Paulo - SP - Brasil, Tel.: 55 11 2137-5400 - São Paulo - SP - Brazil
E-mail: rbo@sbot.org.br

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[1] *Corresponding author: Av. Roberto Silveira 187/601, Centro, CEP 25685-040, Petrópolis, RJ, Brazil. E-mail: plabronici@globo.com.