Analysis on the serum levels of the biomarker CTX-II in professional indoor soccer players over the course of one season

Severino, Rodrigo Miziara; Jorge, Pedro Baches; Martinelli, Mauro Olivo; Lima, Marcos Vaz de; Severino, Nilson Roberto; Duarte Junior, Aires

doi:10.1016/j.rboe.2015.04.001

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Original Articles • Rev. bras. ortop. 50 (3) • May-Jun 2015 • https://doi.org/10.1016/j.rboe.2015.04.001 copy

Analysis on the serum levels of the biomarker CTX-II in professional indoor soccer players over the course of one season ^☆ ☆ Work developed in the Department of Orthopedics and Traumatology, Santa Casa de São Paulo, SP, Brazil

Authorship SCIMAGO INSTITUTIONS RANKINGS

OBJECTIVE:

The aim of this study was to analyze the blood serum levels of CTX-II in professional indoor soccer players, at three different times during one season: at the start of the pre-season, four months later (a time that marks the middle of the season) and at the end of the season.

METHODS:

Fourteen male soccer players of mean age 19 years were included. Blood samples of 3 mL were collected from each individual. The samples were analyzed by means of Elisa tests.

RESULTS:

There was a significant increase in the serum level of CTX-II in the indoor soccer players, from the beginning to the end of the season (p< 0.01).

CONCLUSION:

These data suggest that joint degradation had occurred in these soccer players, by the end of this period. It is evident that further studies are needed, with methodological rigor, so as to make an effective contribution toward precise elucidation of the etiology of this osteoarthritis and its relationship with the biomarkers, as a tool for early diagnosis.

Osteoarthritis; Joint cartilage; Pharmacological biomarkers

	Age	Intensity of pain	Beginning of season	Middle of season	End of season
Player 1	19	No pain	0.321	0.328	0.328
Player 2	18	No pain	0.201	0.278	0.401
Player 3	19	Occasional non-limiting pain	0.182	0.331	0.551
Player 4	20	No pain	0.825	1.121	2.537
Player 5	20	Occasional non-limiting pain	0.312	0.298	0.399
Player 6	19	Occasional non-limiting pain	0.311	0.315	0.324
Player 7	19	Limiting pain	0.299	0.311	0.324
Player 8	20	Occasional non-limiting pain	0.282	0.301	0.309
Player 9	20	No pain	0.311	0.315	0.497
Player 10	20	Occasional non-limiting pain	0.892	2.012	2.349
Player 11	17	No pain	0.312	0.299	0.395
Player 12	19	No pain	0.287	0.277	0.268
Player 13	17	Occasional non-limiting pain	0.347	0.521	0.577
Player 14	19	No pain	0.247	0.317	0.378
Mean (SD)	19		0.366 ± 0.214	0.5 ± 0.485	0.685 ± 0.751

Comparison	Mean difference	p
Complete data
Beginning vs. middle	0.134	0.06
Middle vs. end	0.186	0.02
Beginning vs. end	0.320	0.003

Reduced data
Beginning vs. middle	0.041	0.19
Middle vs. end	0.069	0.06
Beginning vs. end	0.109	0.01

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[1] * Corresponding author. E-mail: pbj1980@hotmail.com (R.M. Severino).

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Analysis on the serum levels of the biomarker CTX-II in professional indoor soccer players over the course of one season ☆ ☆ Work developed in the Department of Orthopedics and Traumatology, Santa Casa de São Paulo, SP, Brazil

OBJECTIVE:

METHODS:

RESULTS:

CONCLUSION:

Analysis on the serum levels of the biomarker CTX-II in professional indoor soccer players over the course of one season ^☆ ☆ Work developed in the Department of Orthopedics and Traumatology, Santa Casa de São Paulo, SP, Brazil