Effects of platelet-rich plasma on lateral epicondylitis of the elbow: prospective randomized controlled trial

Palacio, Evandro Pereira; Schiavetti, Rafael Ramos; Kanematsu, Maiara; Ikeda, Tiago Moreno; Mizobuchi, Roberto Ryuiti; Galbiatti, José Antônio

doi:10.1016/j.rboe.2015.03.014

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Original Articles • Rev. bras. ortop. 51 (1) • jan-feb 2016 • https://doi.org/10.1016/j.rboe.2015.03.014 copy

Effects of platelet-rich plasma on lateral epicondylitis of the elbow: prospective randomized controlled trial^{^☆} ☆ Work developed in the Department of Orthopedics, Traumatology and Sports and Exercise Medicine, Faculdade de Medicina de Marília (FAMEMA), Marília, SP, Brazil.

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

OBJECTIVE:

To evaluate the effects of platelet-rich plasma (PRP) infiltration in patients with lateral epicondylitis of the elbow, through analysis of the Disabilities of the Arm, Shoulder and Hand (DASH) and Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaires.

METHODS:

Sixty patients with lateral epicondylitis of the elbow were prospectively randomized and evaluated after receiving infiltration of three milliliters of PRP, or 0.5% neocaine, or dexamethasone. For the scoring process, the patients were asked to fill out the DASH and PRTEE questionnaires on three occasions: on the day of infiltration and 90 and 180 days afterwards.

RESULTS:

Around 81.7% of the patients who underwent the treatment presented some improvement of the symptoms. The statistical tests showed that there was evidence that the cure rate was unrelated to the substance applied (p = 0.62). There was also intersection between the confidence intervals of each group, thus demonstrating that the proportions of patients whose symptoms improved were similar in all the groups.

CONCLUSION:

At a significance level of 5%, there was no evidence that one treatment was more effective than another, when assessed using the DASH and PRTEE questionnaires.

Keywords:
Platelet-rich plasma; Tendinopathy; Tennis elbow

Group	Minimum score	Maximum score	Median	Mean	Standard error
A	25.0	73.3	49.2	49.7	3.0
B	15.0	75.8	40.4	44.3	4.4
C	22.5	82.5	40.8	45.7	3.8

Group	Minimum score	Maximum score	Median	Mean	Standard error
A	0.8	71.7	10.2	16.6	3.8
B	0.0	80.8	12.1	19.8	4.9
C	1.7	79.2	5.0	10.7	4.0

Group	Minimum score	Maximum score	Median	Mean	Standard error
A	18.0	82.5	52.5	51.7	4.4
B	17.0	83.5	35.8	42.9	4.3
C	24.5	88.5	37.0	47.1	4.9

Group	Minimum score	Maximum score	Median	Mean	Standard error
A	1.5	80.0	9.5	15.5	3.9
B	0.0	85.0	12.8	21.8	5.5
C	0.5	91.5	6.5	13.0	4.7

Group	n	%	Standard error	95% CI
A	20	90.0	6.8	[68.3–98.8]
B	20	65.0	10.9	[40.8–94.6]
C	20	90.0	6.8	[68.3–98.8]

Group	n	%	Standard error	95% CI
A	20	90.0	6.8	[68.3–98.8]
B	20	85.0	8.2	[62.1–96.8]
C	20	90.0	6.9	[68.3–98.8]

	PRTEE
	Without improvement	With improvement	Total
Dash
Without improvement	10.0	8.3	18.3
With improvement	1.7	80.0	81.7
Total	11.7	88.3	100

Sociedade Brasileira de Ortopedia e Traumatologia Al. Lorena, 427 14º andar, 01424-000 São Paulo - SP - Brasil, Tel.: 55 11 2137-5400 - São Paulo - SP - Brazil
E-mail: rbo@sbot.org.br

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[1] * Corresponding author. E-mail:palacio@famema.br (E.P. Palacio).

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Effects of platelet-rich plasma on lateral epicondylitis of the elbow: prospective randomized controlled trial☆ ☆ Work developed in the Department of Orthopedics, Traumatology and Sports and Exercise Medicine, Faculdade de Medicina de Marília (FAMEMA), Marília, SP, Brazil.

ABSTRACT

OBJECTIVE:

METHODS:

RESULTS:

CONCLUSION:

Effects of platelet-rich plasma on lateral epicondylitis of the elbow: prospective randomized controlled trial^{^☆} ☆ Work developed in the Department of Orthopedics, Traumatology and Sports and Exercise Medicine, Faculdade de Medicina de Marília (FAMEMA), Marília, SP, Brazil.