ABSTRACT
Objective:
Evaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty.
Methods:
101 patients were randomized into two groups: the tranexamic acid group (n = 51) and the placebo group (n = 50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate.
Results:
Comparing the groups, there were statistically significant differences (p < 0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion.
Conclusion:
The use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty.
Keywords:
Tranexamic acid; Bleeding; Orthopedic; Total knee arthroplasty; Blood transfusion; Blood volume