Revista Brasileira de Farmacognosia
Print version ISSN 0102-695X
On-line version ISSN 1981-528X
ESTEVAM, Charles S. et al. Chemical constituents and in vivo preliminary evaluation of antimalarial activity of Ouratea nitida Aubl. (Ochnaceae). Rev. bras. farmacogn. [online]. 2005, vol.15, n.3, pp.195-198. ISSN 0102-695X. http://dx.doi.org/10.1590/S0102-695X2005000300005.
This work describes the isolation of triterpenes (3,4-seco-friedelan-3-oic acid, friedelin, and b-amyrin) and other compounds (p-hydroxybenzoic acid ethyl ester and tetracosane) as well as a preliminary evaluation of in vivo antimalarial activity of the extracts from the leaves of Ouratea nitida Aubl. Qualitative analysis by GC-MS of an apolar fraction from the hexane extract was also carried out. Methyl and ethyl esters of lauric, myristic, palmitic, stearic and oleic acids, methyl ester of pentadecanoic, heptadecanoic, arachidonic, beenic and lignoceric acids, and ethyl ester of linoleic acid were found to be the main constituents while n-butyl stearate, tetracosane and 6,10,14-trimetthyl-2-pentadecanone were the minor. All isolated compounds were identified on basis of the spectral data (IR, MS and NMR, including DEPT) and are being described for the first time in this specie.
Keywords : Ouratea nitida; Ochnaceae; triterpenes; antimalarial activity; GC-MS.