Abstract

BEZERRA-SANTOS, C.R.; PECANHA, L.M.T.  and  PIUVEZAM, M.R.. Cissampelos sympodialis Eichl. (Menispermaceae) inhibits anaphylactic shock reaction in murine allergic model. Rev. bras. farmacogn. [online]. 2005, vol.15, n.4, pp. 287-291. ISSN 0102-695X.  http://dx.doi.org/10.1590/S0102-695X2005000400004.

The murine model of OVA-induced immediate allergic reaction was used to evaluate the effectiveness of intraperitoneal sub-acute treatment with the leaf hydroalcoholic extract of Cissampelos sympodialis (AFL) in the anaphylactic shock reaction, IgE production and the background proliferative response. BALB/c mice treated with AFL ranging from 200 to 400 mg/kg/day for 5 days before and during OVA-sensitization strongly reduced the animal death and promoted reduction in total and OVA-specific serum IgE level. Spleen cells from AFL-treated sensitized animals showed a decreased proliferative background response when compared with non-sensitized animals. These results demonstrated that sub-acute intraperitoneal treatment with Cissampelos sympodialis extract has an anti-allergic effect.

Keywords : Cissampelos sympodialis; BALB/c mice; sub-acute treatment; anaphylactic shock reaction; Immunoglobulin E.