Abstract

DEUSCHLE, Régis A. N. et al. Fractionation of dichlorometane extract from Senecio desiderabilis Vellozo and evaluation of the antimicrobial activity. Rev. bras. farmacogn. [online]. 2007, vol.17, n.2, pp. 220-223. ISSN 0102-695X.  http://dx.doi.org/10.1590/S0102-695X2007000200015.

The present work describes the evaluation of the antimicrobial activity of a sesquiterpene fraction obtained from CH₂Cl₂ extract of Senecio desiderabilis Vellozo (Asteraceae), and of germacrene D isolated from it. The sesquiterpene fraction and the isolated substance were obtained by column chromatography and analysed by GC-MS. Substance identification was carried out by NMR. The antimicrobial activity was assayed by broth microdilution method, as preconized by NCCLS in the documents M27-A for yeasts and M7-A4 for bacteria. The sesquiterpene fraction showed moderated antimicrobial activity, and germacrene D did not inhibit the tested microorganisms.

Keywords : Senecio desiderabilis; Asteraceae; antimicrobial activity; sesquiterpene; germacrene D.