Abstract

COSTA, Elson A. et al. Analgesic and anti-inflammatory effects of Cheiloclinium cognatum root barks. Rev. bras. farmacogn. [online]. 2007, vol.17, n.4, pp. 508-513. ISSN 0102-695X.  http://dx.doi.org/10.1590/S0102-695X2007000400006.

Cheiloclinium cognatum (Hippocrateaceae) has been used in folk medicine to treat fever and edema. In this paper, we report the anti-inflammatory and analgesic activities of the crude dichloromethane extract (DECc) from C. cognatum root barks collected in Auguste de Saint Hilaire wood at Universidade Federal de Goiás. Doses of 0.1, 0.3 and 1.0 g/kg caused a dose-dependent inhibition of croton oil-induced ear edema in mice equivalent to 21, 30 and 51%, respectively. There was a significant increase in analgesic-meter-induced tail flick test equivalent to 105, 189 and 200% of increase tail flick reaction time. These results allowed to suggest that C. cognatum could be a source of new compounds which anti-inflammatory and analgesic activities.

Keywords : Cheiloclinium cognatum; Hippocrateaceae; anti-inflammatory effect; analgesic activity; ear edema; peritonitis.