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Revista Brasileira de Farmacognosia

Print version ISSN 0102-695X

Abstract

COSTA, Vicente C. O. et al. Chemical composition and modulation of bacterial drug resistance of the essential oil from the leaves of Rollinia leptopetala R. E. Fries. Rev. bras. farmacogn. [online]. 2008, vol.18, n.2, pp. 245-248. ISSN 0102-695X.  http://dx.doi.org/10.1590/S0102-695X2008000200019.

The essential oil from the leaves of Rollinia leptopetala was obtained by hydrodistillation in Clevenger's apparatus and its chemical composition was analyzed by GC-MS. With this technique could be identified 22 constituents in a complex mixture of monoterpenes (54.5%) and sesquiterpenes (45.5%). The main component found in the leaves was the bicyclogermacrene (22.47%). The essential oil was assayed against a strain of Staphylococcus aureus possessing efflux mechanism of resistance to norfloxacin. Although the essential oil did not display relevant antibacterial activity in vitro, it modulated the activity of the norfloxacin, i.e. in combination with the antibiotic it was observed a fourfold reduction in the minimum inhibitory concentration for norfloxacin, indicating inhibition of efflux pump.

Keywords : Rollinia leptopetala; essential oil; GC-MS; Staphylococcus aureus; modulation of drug resistance; efflux pump inhibitor.

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