SciELO - Scientific Electronic Library Online

vol.18 issue3Anatomical considerations and essential oil analysis of the hypanthium and the fruit of Hennecartia omphalandra J. Poisson (Monimiaceae)Antimicrobial activity of Lippia alba (Mill.) N. E. Brown (Verbenaceae) author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista Brasileira de Farmacognosia

Print version ISSN 0102-695XOn-line version ISSN 1981-528X


SILVERIO, Marcelo S. et al. Pharmacological properties of the ethanol extract from Eremanthus erythropappus (DC.) McLeisch (Asteraceae). Rev. bras. farmacogn. [online]. 2008, vol.18, n.3, pp.430-435. ISSN 0102-695X.

The present work investigated the antinociceptive, anti-inflammatory and antiulcerogenic activities of Eremanthus erythropappus ethanol extract. The tests were carried out by acetic acid writhing, paw licking induced by formalin, hot plate, indomethacin- and ethanol-induced ulcer. The doses of 50, 100 and 200 mg/kg inhibited the contortions in 43.07, 69.34 and 70.07%, respectively. Both phases of paw lick were reduced at the tested doses, while reaction time at hot plate had significant effect at 200 mg/kg. The paw edema was decreased in 23.81% (100 mg/kg) and 47.62% (200 mg/kg). The index of ulceration induced by indomethacin was reduced at the doses of 100 and 200 mg/kg, while 200 mg/kg decreased the gastric volume and pH. The index of ulceration and gastric volume induced by ethanol was reduced at 200 mg/kg, while the pH increased at 100 and 200 mg/kg. The results indicate that the ethanol extract from E. erythropappus may constitute a potential target for the use in therapies of the pain, inflammation and ulcer.

Keywords : Eremanthus erythropappus; antinociceptive activity; anti-inflammatory activity; antiulcerogenic activity.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License