SciELO - Scientific Electronic Library Online

vol.19 issue2AAcute and subacute toxicity studies of the latex and of the ethanolic extract of the leaves of Synadenium umbellatum Pax in ratsMutagenic activity study of the plants Euphorbia milii and Ricinus communis L. through the Allium cepa test author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista Brasileira de Farmacognosia

Print version ISSN 0102-695XOn-line version ISSN 1981-528X


SOUZA, Aline de et al. Continuous treatment with alcohol extract from Pterogyne nitens leaves does not alter typical variables of experimental diabetes. Rev. bras. farmacogn. [online]. 2009, vol.19, n.2a, pp.412-417. ISSN 0102-695X.

Kaempferitrin (a flavonoid) and galegin (an alkaloid) have been indicated as hypoglycemic agents. Leaves of Pterogyne nitens, which contain both compounds, might be antidiabetic. We therefore treated diabetic rats with these leaves to observe the effects on their glycemia and physiological variables. Streptozotocin-diabetic rats were given ethanolic extract of the leaves (76 mg in 0.5 mL 10% glycerol) (DTPn), twice a day by gavage for 32 days. Diabetic controls were given 0.5 mL 10% glycerol (DTG), insulin (2.5 U in 0.3 mL) (DTI) or 0.5 mL water (DTA). During this treatment, we measured level of glycemia, the body weight, daily food and water intake and urine volume, once each week. The results for the DTPn, DTG and DTA groups all differed significantly from these for the DTI group. The latter exhibited greater body weights and lower physiological variables and glycemia than the groups DTPn, DTG and DTA, all of which gave similar results. From the data for DTI rats, we conclude that the study model was appropriate. Therefore, the plant extract (plus glycerol) neither improved nor worsened the diabetic state of the rats. It is possible that this plant might ameliorate diabetes experimental if the dose of extract, treatment route or severity of induced diabetes were altered.

Keywords : Antidiabetic plant; diabetic rats; liquid and food intake; urinary volume; plasma glucose.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License