Revista Brasileira de Farmacognosia
Print version ISSN 0102-695X
OLIVEIRA, Rafael R. B. et al. Antinociceptive effect of the ethanolic extract of Amburana cearensis (Allemão) A.C. Sm., Fabaceae, in rodents. Rev. bras. farmacogn. [online]. 2009, vol.19, n.3, pp.672-676. ISSN 0102-695X. http://dx.doi.org/10.1590/S0102-695X2009000500004.
The ethanolic extract of the trunk bark of Amburana cearensis (EEA) was examined for its oral (p.o.) analgesic activity at the doses of 100, 200 and 400 mg/kg body weight. In the acetic acid-induced writhing test, the EEA (200 and 400 mg/kg, p.o.) reduced the number of writhing by 33.4% and 40.7%, respectively. Additionally, EEA (100, 200 and 400 mg/kg, p.o.) decreased by 77.5%, 79.7 and 91.3%, respectively, the paw liking time in the second phase of the formalin test. Therefore, EEA showed a dose-dependent analgesic effect in formalin test and was effective in reducing writhing in mice.
Keywords : Amburana cearensis; Fabaceae; antinociceptive activity; medicinal plant.