Abstract

SILVA, Cinara V. da et al. Evaluation of the antimicrobial activity of two Rutaceae species from the Brazilian Northeast. Rev. bras. farmacogn. [online]. 2010, vol.20, n.3, pp. 355-360. ISSN 0102-695X.  http://dx.doi.org/10.1590/S0102-695X2010000300011.

With the increase in bacterial resistance to available antibiotics, it became imperative to search for new drugs or prototypes. The secondary metabolites produced by some plants as coumarins, alkaloids and terpenoids have several biological activities, among them, antibiotic activity. The objective of this study was to evaluate the antimicrobial activity in vitro by the disk diffusion method, from different parts of two species belonging to the family Rutaceae, collected in the Chapada Diamantina, Bahia, Brazil: Spiranthera odoratissima A. St Hil. and Zanthoxylum stelligerum Turcz., and the alkaloid dihydrochelerythrine, isolated from the methanolic extract of Z. stelligerum front of standard strains of microorganisms and clinical isolates. The results indicate that the extract from the roots of Z. stelligerum and the alkaloid had antimicrobial properties against Gram positive and yeast strains. The E. coli was the only Gram negative strain that was sensitive to extract and the alkaloid.

Keywords : Zanthoxylum stelligerum; Spiranthera odoratissima; antimicrobial activity; dihydrochelerythrine; Rutaceae.