Abstract

ANDRADE, Alexandre M. et al. Preliminary study on the anti-inflammatory and antioxidant activities of the leave extract of Hyptis fruticosa Salzm. ex Benth., Lamiaceae. Rev. bras. farmacogn. [online]. 2010, vol.20, n.6, pp. 962-968.  Epub Oct 29, 2010. ISSN 0102-695X.  http://dx.doi.org/10.1590/S0102-695X2010005000034.

Various species of Hyptis are used in folk medicine as anti-inflammatory. In order to evaluate the actions of Hyptis fruticosa Salzm. ex Benth., Lamiaceae, studies were performed on anti-inflammatory and antioxidant activities. The ethanol extract (EE) of H. fruticosa leaves and its n-CH, CHCl, EtOAc, and MeOH/HO partitions were used in the following experiments. Oral treatment with the EE of H. fruticosa leaves (100, 200, and 400 mg/kg) or its n-C₆H₁₄, EtOAc, and MeOH/H₂O partitions (50, 100, and 200 mg/kg) elicited inhibitory activity (p<0.05) on carrageenan-induced oedema formation and leukocyte migration into the peritoneal cavity in rats. However, the CHCl₃ partition did not show any inhibitory effect on paw oedema and peritonitis experimental models. The EE and EtOAc partition present highest antioxidant potential (IC50 = 35.00±1.01 and 36.67±2.65 µg/mL DPPH, respectively), similar to the reference compound (IC50 = 16.67±1.21 µg/mL). In conclusion, H. fruticosa shows anti-inflammatory and antioxidant activities.

Keywords : Anti-inflammatory; antioxidant; cellular migration; Hyptis fruticosa; Lamiaceae; oedema.