Abstract

SIQUEIRA, Carlos A. T. et al. Chemical constituents of the volatile oil from leaves of Annona coriacea and in vitro antiprotozoal activity. Rev. bras. farmacogn. [online]. 2011, vol.21, n.1, pp. 0-0.  Epub Nov 26, 2010. ISSN 0102-695X.  http://dx.doi.org/10.1590/S0102-695X2011005000004.

The essential oil of the leaves from Annona coriacea Mart., Annonaceae, was extracted by hydrodistillation in a Clevenger apparatus and analyzed by GC/MS and GC/FID. The oil yield was 0.05% m/m. Sixty compounds were identified, in a complex mixture of sesquiterpenes (76.7%), monoterpenes (20.0%) and other constituents (3.3%). Bicyclogermacrene was its major compound (39.8%) followed by other sesquiterpenes. Most of the monoterpenes were in low concentration (<1%). Only β-pinene and pseudolimonene presented the highest level of 1.6%. The volatile oil presented anti-leishmanial and trypanocidal activity against promastigotes of four species of Leishmania and trypomastigotes of Trypanosoma cruzi, showing to be more active against Leishmania (L.) chagasi (IC50 39.93 µ g/mL) (95% CI 28.00-56.95 µ g/mL).

Keywords : Annona coriacea Mart.; Annonaceae; volatile oil; GC/MS-GC/FID analysis; in vitro antiprotozoal activity.