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Revista Brasileira de Farmacognosia
Print version ISSN 0102-695X
SILVA, Déborah S. B. S. et al. Genotoxicity and cytotoxicity of Erythrina velutina Willd., Fabaceae, on the root meristem cells of Allium cepa. Rev. bras. farmacogn. [online]. 2011, vol.21, n.1, pp.92-97. Epub Feb 25, 2011. ISSN 0102-695X. http://dx.doi.org/10.1590/S0102-695X2011005000024.
The effects of the decoction of Erythrina velutina Willd., Fabaceae, were investigated using the root meristem cells of Allium cepa L., Amaryllidaceae. Ten concentrations of the aqueous extract (0.125 to 1.25%) of this medicinal plant were analyzed at both macroscopic and microscopic levels. All concentrations showed root growth inhibition after 96 h treatment. Although there were no significant differences between the mitotic indexes of any concentration and the control, there were changes in the frequencies of cell stages at three different concentrations. Additionally, the presence of five different cells abnormalities was recorded: chromosome bridging, lagging chromosomes, chromosome fragments, disturbed metaphase and disturbed anaphase. These results suggest inhibitory and genotoxic activity of the decoction of E. velutina on Allium cepa.
Keywords : Erythrina velutina; Allium cepa; root growth; mitotic index; chromosomal aberration.