Revista Brasileira de Farmacognosia
Print version ISSN 0102-695X
OLIVEIRA, Susy Mary Souto de et al. Modulation of drug resistance in Staphylococcus aureus by extract of mango (Mangifera indica L., Anacardiaceae) peel. Rev. bras. farmacogn. [online]. 2011, vol.21, n.1, pp. 190-193. Epub Feb 04, 2011. ISSN 0102-695X. http://dx.doi.org/10.1590/S0102-695X2011005000014.
In an ongoing project to evaluate natural compounds isolated from by-products or wastes from vegetables and fruits (edible plants) as modulators of antibiotic resistance, ethanol extract from mango peel was investigated using Staphylococcus aureus strains possessing efflux mechanisms of resistance to norfloxacin, erythromycin and tetracycline. The minimum inhibitory concentrations (MIC) of the antibiotics were determined by the micro dilution assay in the absence and in the presence of sub-inhibitory mango peel extract concentration. Although the extract did not display relevant antibacterial activity (MIC>2048 µg/mL), it modulated the activity of antibiotics, i.e. in combination with antibiotics (at 512 µg/mL), a four-fold reduction in the MIC values for tetracycline and erythromycin was observed. The results presented here indicates that mango peel could serve as a source of potential adjuvant of antibiotics which add value to this mango by-product.
Keywords : Mangifera indica L; mango peel; ethanol extract; Staphylococcus aureus; modulation of drug resistance; efflux pump inhibitor.