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vol.21 issue2Search for cytotoxic agents in multiple Laurencia complex seaweed species (Ceramiales, Rhodophyta) harvested from the Atlantic Ocean with emphasis on the Brazilian State of Espírito SantoSesquiterpenes from the essential oil of Laurencia dendroidea (Ceramiales, Rhodophyta): isolation, biological activities and distribution among seaweeds author indexsubject indexarticles search
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Revista Brasileira de Farmacognosia

Print version ISSN 0102-695X


MATTOS, Bianca B. et al. Glycolipids from macroalgae: potential biomolecules for marine biotechnology?. Rev. bras. farmacogn. [online]. 2011, vol.21, n.2, pp.244-247.  Epub Apr 01, 2011. ISSN 0102-695X.

Brown, red and green algae from the Southeastern coast of Brazil were successively extracted with chloroform/methanol 2:1 and 1:2 (v/v). The crude lipid extract was partitioned according to Folch and the lower phase enriched in glycolipids was fractionated on a silica gel column chromatography eluted with chloroform, acetone and methanol. Three major orcinol-reactive bands present in the acetone and methanol fractions were detected by thin-layer chromatography with chromatographic mobilities corresponding to sulfoglycolipids and glycosyldiacylglycerols. These fractions exhibited potent antiviral activity against HSV-1-ACVs and HSV-1-ACVr and present low toxicity for cell cultures. Purification and identification of these bioactive glycolipids will be necessary in order to elucidate their primary structures and mechanism of action.

Keywords : marine macroalgae; glycolipids; antiviral activity.

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