Revista Brasileira de Farmacognosia
Print version ISSN 0102-695X
MATTOS, Bianca B. et al. Glycolipids from macroalgae: potential biomolecules for marine biotechnology?. Rev. bras. farmacogn. [online]. 2011, vol.21, n.2, pp. 244-247. Epub Apr 01, 2011. ISSN 0102-695X. http://dx.doi.org/10.1590/S0102-695X2011005000056.
Brown, red and green algae from the Southeastern coast of Brazil were successively extracted with chloroform/methanol 2:1 and 1:2 (v/v). The crude lipid extract was partitioned according to Folch and the lower phase enriched in glycolipids was fractionated on a silica gel column chromatography eluted with chloroform, acetone and methanol. Three major orcinol-reactive bands present in the acetone and methanol fractions were detected by thin-layer chromatography with chromatographic mobilities corresponding to sulfoglycolipids and glycosyldiacylglycerols. These fractions exhibited potent antiviral activity against HSV-1-ACVs and HSV-1-ACVr and present low toxicity for cell cultures. Purification and identification of these bioactive glycolipids will be necessary in order to elucidate their primary structures and mechanism of action.
Keywords : marine macroalgae; glycolipids; antiviral activity.