SciELO - Scientific Electronic Library Online

vol.21 issue3In vitro cytotoxic activity of Brazilian Middle West plant extractsPreliminary evaluation of antitumor effect and induction apoptosis in PC-3 cells of extract from Patrinia heterophylla author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista Brasileira de Farmacognosia

Print version ISSN 0102-695X


NABAVI, Seyed Fazel et al. Biological activities of Juglans regia flowers. Rev. bras. farmacogn. [online]. 2011, vol.21, n.3, pp.465-470.  Epub June 03, 2011. ISSN 0102-695X.

Antidepressant, anti-inflammatory, antihypoxic and antioxidant activities of methanol extract of Juglans regia L., Juglandaceae, flower were investigated. Antidepressant activity was examined by forced swimming test and tail suspension test in mice. Antihypoxic activity was investigated in haemic and circulatory models. The effects were pronounced in both models. It produced statistically significant anti-inflammatory activity in carrageenan induced edema at nearly all doses, compared to control groups. IC50 for DPPH radical-scavenging activity was 674±27.6 µg mL-1. Extract showed good Fe2+ chelating ability (IC50 43±1.5 µg mL-1). It exhibited low antioxidant activity in linoleic acid peroxidation test. Its pharmacological effects may be attributed, in part, to the presence of phenols and ISSN 0102-695X flavonoids in the extract.

Keywords : antidepressant activity; antioxidant activitywhen; antihypoxic activity; Juglans regia.

        · text in English     · English ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License