Revista Brasileira de Farmacognosia
Print version ISSN 0102-695X
COSTA, Ane R. T. et al. Dissolution test of herbal medicines containing Passiflora sp.. Rev. bras. farmacogn. [online]. 2011, vol.21, n.3, pp.525-531. Epub May 20, 2011. ISSN 0102-695X. http://dx.doi.org/10.1590/S0102-695X2011005000083.
The dissolution test is an essential tool to assess the quality of herbal medicines in the solid dosage form for oral use. This work aimed to evaluate the dissolution behavior of three herbal medicines in the form of capsules and tablet containing Passiflora, produced with powder or dried extract. Assay of total flavonoids and dissolution methods were validated and obtained results allowed the quantification of flavonoids with precision, accuracy and selectivity. The percentage of total flavonoids found was 2% for capsule A (containing only powder), 0.97% for capsule B (containing only dried extract) and 5.5% for tablet. Although the content was lower, the release of flavonoids present in the capsule containing dried extract was 12% higher over 30 min, with dissolved percentage values of 87 and 75, for the capsules containing extract and powder, respectively. The tablet containing dried extract presented dissolution of 76%, despite the higher content of flavonoids, which may be due to pharmacotechnical problems. Obtained data demonstrated the need to implement these tests in the quality control of herbal medicines, confirming the release of the active ingredients that underlie the pharmacological action of these medicines.
Keywords : flavonoids; natural product; Passiflora; passion fruit; quality control.