Resumo

GROSSO, Clara et al. Chemical composition and biological screening of Capsella bursa-pastoris. Rev. bras. farmacogn. [online]. 2011, vol.21, n.4, pp. 635-643.  Epub 17-Jun-2011. ISSN 0102-695X.  http://dx.doi.org/10.1590/S0102-695X2011005000107.

Capsella bursa-pastoris (L.) Medik. (Brassicaceae) is a wild herb with high nutritional value that can be eaten raw or cooked. A metabolomic study was performed with different extracts of its aerial parts that were tested concerning their antiradical, acetylcholinesterase inhibitory and antibacterial activities. Phenolic compounds were identified and quantified by HPLC-DAD, organic acids and amino acids were determined by HPLC-UV, while free fatty acids and sterols were analysed by GC-ITMS. The vegetal material was rich in kaempferol-3-O-rutinoside (mean value 2247.09 mg/kg of dry plant), quinic acid (95628.00 mg/kg of dry plant), arginine (mean value of 1.18 mg/kg of dry plant), palmitic acid (284.48 mg/kg) and β-sitosterol (28%). The extracts presented a concentration-dependent antiradical activity (against DPPH^•, O₂^•- and LOO^•), being most effective against ^•NO (EC25 0.20 µg/mL). In addition, the extracts were also acetylcholinesterase inhibitors and antibacterial active, revealing that, besides the plant's good nutritional value, it presents important biological properties as well.

Palavras-chave : acetylcholinesterase inhibition antibacterial activity; antioxidant activity; Capsella bursa-pastoris; metabolic profile.