Abstract

GILARDONI, Gianluca et al. Phytochemical researches and antimicrobial activity of Clinopodium nubigenum Kunth (Kuntze) raw extracts. Rev. bras. farmacogn. [online]. 2011, vol.21, n.5, pp. 850-855.  Epub Aug 12, 2011. ISSN 0102-695X.  http://dx.doi.org/10.1590/S0102-695X2011005000139.

The essential oil of the species Clinopodium nubigenum (Kunth) Kuntze, Lamiaceae, was analyzed by GC-MS and GC-FID, taking into account the more recent literature. Among the seventy compounds identified, the majority are oxygenated monoterpenoids. The essential oil, tested for antimicrobial activity, resulted effective in vitro against Candida albicans. From the aqueous MeOH extract of the aerial parts of the plant two nonvolatile compounds, named schizonepetoside A and schizonepedoside C, have been isolated. They are rare glycosyl terpenoids, which were previously isolated from only one plant, but never found before in the genus Clinopodium.

Keywords : antimicrobial activity; Clinopodium nubigenum; essential oil; GC-MS; ¹H-NMR; ¹³C-NMR; schizonepetoside; tipo de cerro.