Revista Brasileira de Farmacognosia
Print version ISSN 0102-695X
KITAGAWA, Rodrigo Rezende; VILEGAS, Wagner; CARLOS, Iracilda Zeppone and RADDI, Maria Stella Gonçalves. Antitumor and immunomodulatory effects of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin. Rev. bras. farmacogn. [online]. 2011, vol.21, n.6, pp.1084-1088. Epub Aug 05, 2011. ISSN 0102-695X. http://dx.doi.org/10.1590/S0102-695X2011005000136.
Large number of quinones has been associated with antitumor, antibacterial, antimalarial and antifungal activities. In this work we describe the effect of the naphthoquinone, 5-methoxy-3,4-dehydroxanthomegnin, on murine tumor cells (LP07 and LM2) and its immunomodulatory effect on nitric oxide (NO) production on LPS-stimulated macrophages. The results have shown that 5-methoxy-3,4-dehydroxanthomegnin was a significant inhibitor of LPS-stimulated NO generation from macrophage (inhibition percentage ranged from 97.4 to 98.9%) and a strong cytotoxic agent against both tumor cells LP07 and LM2 (CI50 6.2±0.36 µM and 74.6±1.9 µM, respectively). These results indicate that the 5-methoxy-3,4-dehydroxanthomegnin may show promising activity in the treatment of murine breast and lung cancer by immunomodulatory and antiproliferative activities.
Keywords : 5-methoxy-3,4-dehydroxanthomegnin; cytotoxic activity; immunomodulatory; naphthoquinone.