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Revista Brasileira de Farmacognosia

Print version ISSN 0102-695X


KITAGAWA, Rodrigo Rezende; VILEGAS, Wagner; CARLOS, Iracilda Zeppone  and  RADDI, Maria Stella Gonçalves. Antitumor and immunomodulatory effects of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin. Rev. bras. farmacogn. [online]. 2011, vol.21, n.6, pp.1084-1088.  Epub Aug 05, 2011. ISSN 0102-695X.

Large number of quinones has been associated with antitumor, antibacterial, antimalarial and antifungal activities. In this work we describe the effect of the naphthoquinone, 5-methoxy-3,4-dehydroxanthomegnin, on murine tumor cells (LP07 and LM2) and its immunomodulatory effect on nitric oxide (NO) production on LPS-stimulated macrophages. The results have shown that 5-methoxy-3,4-dehydroxanthomegnin was a significant inhibitor of LPS-stimulated NO generation from macrophage (inhibition percentage ranged from 97.4 to 98.9%) and a strong cytotoxic agent against both tumor cells LP07 and LM2 (CI50 6.2±0.36 µM and 74.6±1.9 µM, respectively). These results indicate that the 5-methoxy-3,4-dehydroxanthomegnin may show promising activity in the treatment of murine breast and lung cancer by immunomodulatory and antiproliferative activities.

Keywords : 5-methoxy-3,4-dehydroxanthomegnin; cytotoxic activity; immunomodulatory; naphthoquinone.

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