Resumen

EL-SEEDI, Hesham R. et al. Anti-schistosomiasis triterpene glycoside from the Egyptian medicinal plant Asparagus stipularis. Rev. bras. farmacogn. [online]. 2012, vol.22, n.2, pp. 314-318.  Epub 06-Ene-2012. ISSN 0102-695X.  http://dx.doi.org/10.1590/S0102-695X2012005000004.

Bioassay-guided isolation using an in vitro assay testing for anti- schistosomiasis yielded a novel triterpene saponin, asparagalin A, from the n-butanol extract of the roots of Asparagus stipularis Forssk., Asparagaceae. The structure was elucidated by spectroscopic analysis and chemical transformations. Administration of asparagalin A resulted in a retardation of worm growth and locomotion at the first day and showed a significant activity of egg-laying suppression at 200 µg/mL concentration.

Palabras llave : anti-schistosomiasis; Asparagus stipularis; Asparagaceae; triterpene glycoside.