SciELO - Scientific Electronic Library Online

vol.22 issue3Chemical composition and anxiolytic-like effects of the Bauhinia platypetalaRelaxant effect of the essential oil of Croton nepetifolius on ovine cervix author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista Brasileira de Farmacognosia

Print version ISSN 0102-695X


LEITE, Ana Carolina C. F. et al. Grandisin caused morphological changes larval and toxicity on Aedes aegypti. Rev. bras. farmacogn. [online]. 2012, vol.22, n.3, pp.517-521.  Epub Jan 24, 2012. ISSN 0102-695X.

Dengue is a tropical disease caused by an arbovirus transmitted by Aedes aegypti. Since no effective vaccine is available for treating dengue, the present study focused on population vector control through investigating the use of the lignan grandisin, isolated from Piper solmsianum C. DC., Piperaceae, against the larvae of A. aegypti. Grandisin caused larval (L3) mortality at LC50 150 µg/mL. Histological analysis on A. aegypti larvae treated with grandisin (LC50 50 µg/mL) showed changes in the anterior-middle midgut, with intense tissue destruction and cell disorganization.

Keywords : Aedes aegypti; Piper solmsianum; histology; toxicity; tropical disease.

        · text in English     · English ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License