SciELO - Scientific Electronic Library Online

 
vol.22 número4Comparison of extraction and transesterification methods on the determination of the fatty acid contents of three Brazilian seaweed speciesUse of geographic information systems (GIS) to identify adequate sites for cultivation of the seaweed Gracilaria birdiae in Rio Grande do Norte, Northeastern Brazil índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Revista Brasileira de Farmacognosia

versión impresa ISSN 0102-695X

Resumen

MACEDO, Nathália Regina Porto Vieira et al. Caulerpin as a potential antiviral drug against herpes simplex virus type 1. Rev. bras. farmacogn. [online]. 2012, vol.22, n.4, pp. 861-867.  Epub 29-Mayo-2012. ISSN 0102-695X.  http://dx.doi.org/10.1590/S0102-695X2012005000072.

About 80% of the human adult population is infected with HSV-1. Although there are many anti-HSV-1 drugs available (acyclovir, ganciclovir, valaciclovir, foscarnet), their continuous use promotes the selection of resistant strains, mainly in ACV patients. In addition to resistance, the drugs also have toxicity, particularly when administration is prolonged. The study of new molecules isolated from green algae with potential antiviral activity represents a good opportunity for the development of antiviral drugs. Caulerpin, the major product from the marine algae Caulerpa Lamouroux (Caulerpales), is known for its biological activities such as antioxidant, antifungal, acetylcholinesterase inhibitor (AChE) and antibacterial activity. In this work, we show that caulerpin could be an alternative to acyclovir as an anti-HSV-1 drug that inhibits the alpha and beta phases of the replication cycle.

Palabras llave : Caulerpa; caulerpin; Herpes simplex type 1; cytotoxicity; antiviral.

        · texto en Inglés     · pdf en Inglés