Anti-inflammatory |
|
Hydroalcoholic extract |
400 mg/kg |
Reduction of paw edema |
Lino et al. (1997)Lino, C.S., Viana, G.S.B., Matos, F.J.A., 1997. Analgesic and antiinflamatory activities of Justicia pectoralis Jacq and its main constituents: coumarin and umbelliferone. Phytother. Res. 11, 211-215.
|
Carrageenan-induced paw edema |
Hydroalcoholic extract |
50 mg/kg (i.p.) |
Inhibition of edema by 24% |
Leal et al. (2000)Leal, L.K.A.M., Ferreira, A.A.G., Bezerra, G.A., Matos, F.J.A., Viana, G.S.B., 2000. Antinociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study. J. Ethnopharmacol. 70, 151-159.
|
|
Standardized dry extract |
100, 200, 400 mg/kg ( p.o .) |
Reduction of paw edema from the third hour at the highest doses |
Fonseca (2009)Fonseca, F.N., (Dissertação de mestrado) 2009. Desenvolvimento tecnológico de fitoproduto a partir de Justicia pectoralis – chambá: obtenção do extrato seco padronizado (CLAE – DAD) e avaliação farmacológica. Fortaleza. Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal do Ceará, pp.131.
|
Human neutrophil degranulation |
Standardized dry extract |
3-100 µg/ml |
Inhibition of myeloperoxidase enzyme release up to 68% at the highest dose. |
Fonseca (2009)Fonseca, F.N., (Dissertação de mestrado) 2009. Desenvolvimento tecnológico de fitoproduto a partir de Justicia pectoralis – chambá: obtenção do extrato seco padronizado (CLAE – DAD) e avaliação farmacológica. Fortaleza. Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal do Ceará, pp.131.
|
|
|
1-100 µg/ml |
Inhibition of myeloperoxidase enzyme release up to 88% at the highest dose. |
Alves (2010)Alves, V.C.C., 2010. Avaliação da toxicidade e potencial antiinflamatório do extrato seco padronizado (CLAE-DAD) de Justicia pectoralis e constituintes químicos em neutrófilos humanos. Fortaleza. Trabalho de Conclusão de Curso, Graduação em Farmácia, Universidade Federal do Ceará, pp. 88.
|
Enzymatic activity of human COX-2 |
Methanolic extract |
1-50 µg/ml |
Inhibition of PGE2 production up to 89% at the highest dose |
Lockleara et al. (2010)Lockleara, T.D., Huanga, Y., Frasor, J., Doyle, B.J., Perez, A., Gomez-Laurito, J., Mahadya, G.B., 2010. Estrogenic and progestogenic effects of extracts of Justicia pectoralis Jacq., an herbal medicine from Costa Rica used for the treatment of menopause and PMS. Maturitas 66, 315-322.
|
Antiasthmatic |
Ovalbumin sensitization and challenge |
Hydroalcoholic extract |
80 mg/kg (p.o.) |
Reduction of airway hyperresponsiveness and bronchoalveolar lavage cytokines |
Moura et al. (2017)Moura, C.T.M., Batista-Lima, F.J., Brito, T.S., Silva, A.A.V., Ferreira, L.C., Roque, C.R., Aragão, K.S., Havt, A., Fonseca, F.N., Leal, L.K.A.M., Magalhães, P.J.C., 2017. Inhibitory effects of a standardized extract of Justicia pectoralis in an experimental rat model of airway hyper-responsiveness. J. Pharm. Pharmacol. 69, 722-732.
|
Antihistamine |
Relaxation of precontracted tracheal segments |
Aqueous extract |
3.3 mg |
Blocks the effect of contraction |
Cameron et al. (2015)Cameron, C., Jacob, A.S., Thomas, E.A., Levy, A.S., 2015. Preliminary investigations of the anti-asthmatic properties of the aqueous extract of Justicia pectoralis (fresh cut). West Indian Med. J. 64, 321-323.
|
Cutaneous papules |
|
|
Gradual reduction in the diameter of the papule |
|
Spasmolytic |
Relaxation of precontracted tracheal segments |
Hydroalcoholic extract |
200, 400 mg/kg |
Concentration-dependent relaxation |
Leal et al. (2000)Leal, L.K.A.M., Ferreira, A.A.G., Bezerra, G.A., Matos, F.J.A., Viana, G.S.B., 2000. Antinociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study. J. Ethnopharmacol. 70, 151-159.
|
Antinociceptive |
Nociception induced by formalin |
Hydroalcoholic extract |
400 mg/kg (p.o.) |
Reduction of the paw licking time in the first phase |
Lino (1995)Lino, C.S., (Dissertação de mestrado) 1995. Efeito farmacológico de Justicia pectoralis Jacq. e seus princípios ativos: cumarina e umbeliferona. Fortaleza. Programa dePós-graduação em Farmacologia, Universidade Federal do Ceará, pp. 113.
|
|
Hydroalcoholic extract |
200, 400 mg/kg ( p.o. ) |
Reduction of paw licking time in both phases |
Leal et al. (2000)Leal, L.K.A.M., Ferreira, A.A.G., Bezerra, G.A., Matos, F.J.A., Viana, G.S.B., 2000. Antinociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study. J. Ethnopharmacol. 70, 151-159.
|
Nociception induced by capsaicin |
Standardized dry extract |
100, 200, 400 mg/kg (p.o.) |
Reduction of paw licking time at all doses |
Fonseca (2009)Fonseca, F.N., (Dissertação de mestrado) 2009. Desenvolvimento tecnológico de fitoproduto a partir de Justicia pectoralis – chambá: obtenção do extrato seco padronizado (CLAE – DAD) e avaliação farmacológica. Fortaleza. Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal do Ceará, pp.131.
|
Abdominal contraction caused by acetic acid |
Hydroalcoholic extract |
200, 400 mg/kg (p.o.) |
Reduction of the number of abdominal contractions by 36 to 64%, respectively |
Leal et al. (2000)Leal, L.K.A.M., Ferreira, A.A.G., Bezerra, G.A., Matos, F.J.A., Viana, G.S.B., 2000. Antinociceptive, anti-inflammatory and bronchodilator activities of Brazilian medicinal plants containing coumarin: a comparative study. J. Ethnopharmacol. 70, 151-159.
|
Anxiolytic |
Elevated plus maze |
Standardized dry extract |
50, 100, 200 mg/kg (p.o.) |
Increase in number of entries and length of stay in open arms |
Venâncio et al. (2011)Venâncio, E.T., Rocha, N.F.M., Rios, E.R., Feitosa, M.L., Linhares, M.I., Melo, F.H.C., Matias, M.S., Fonseca, F.N., Sousa, F.C.F., Leal, L.K.A.M., Fonteles, M.M.F., 2011. Anxiolytic-like effects of standardized extract of Justicia pectoralis (SEJP) in mice: involvement of GABA/benzodiazepine in receptor. Phytoter. Res. 25, 444-450.
|
Light/dark |
Standardized dry extract |
50, 100 and 200 mg/kg (p.o.) |
Increased length of stay into the clear compartment |
Venâncio et al. (2011)Venâncio, E.T., Rocha, N.F.M., Rios, E.R., Feitosa, M.L., Linhares, M.I., Melo, F.H.C., Matias, M.S., Fonseca, F.N., Sousa, F.C.F., Leal, L.K.A.M., Fonteles, M.M.F., 2011. Anxiolytic-like effects of standardized extract of Justicia pectoralis (SEJP) in mice: involvement of GABA/benzodiazepine in receptor. Phytoter. Res. 25, 444-450.
|
Sedative |
Sleep time induced by thiopental |
Standardized dry extract |
5, 20, 80 mg/kg (p.o.) |
Increase the sleep time of the animals at the highest dose |
Rodríguez Chanfrau et al. (2008)Rodríguez Chanfrau, Jorge, E., Orestes, D., José, M., 2008, July–Sept. Method for coumarin quantification in dry extracts from Justicia pectoralis Jacq. Rev. Cubana Pl. Med.
|
Anticonvulsant |
Seizure induced by |
Picrotoxin |
Standardized dry extract |
50, 100 mg/kg (p.o.) |
Increased latency of first convulsion and latency to death |
Venâncio (2015)Venâncio, E.T., 2015. Avaliação do potencial anticonvulsivante do extrato padronizado de Justicia pectoralis (chambá): estudo de neuroproteção e mecanismo de ação. Fortaleza. Tese de Doutorado, Pós-graduação em Farmacologia, Universidade Federal do Ceará, pp. 182.
|
Strychnine electroshock pilocarpine |
25, 50, 100 mg/kg (p.o.) |
Gastroprotective |
Gastric ulcer induced by ethanol |
Standardized dry extract |
100, 200, 400 mg/kg (p.o.) |
Prior administration of the extract reduced the formation of ulcer |
Fonseca and Leal (2012)Fonseca, F.N., Leal, L.K.A.M., 2012. Gastroprotective and microbial effects of standardized extract of Justicia pectoralis. In: XXII Simpósio de Plantas Medicinais do Brasil. Bento Gonçalves, Rio Grande do Sul.
|
Hormonal |
Binding and gene expression of estradiol and progesterone receptors in cell culture |
Methanolic extract |
20, 50 µg/ml |
Increased gene expression and agonist effect of estradiol and progesterone receptors |
Lockleara et al. (2010)Lockleara, T.D., Huanga, Y., Frasor, J., Doyle, B.J., Perez, A., Gomez-Laurito, J., Mahadya, G.B., 2010. Estrogenic and progestogenic effects of extracts of Justicia pectoralis Jacq., an herbal medicine from Costa Rica used for the treatment of menopause and PMS. Maturitas 66, 315-322.
|
Antimicrobial |
Agar plate |
Ethyl acetate and petroleum ether fraction |
1 mg/ml |
Inhibition of bacterial growth of several gram-positive and gram-negative strains |
Chariandy et al. (1999)Chariandy, C.M., Seaforth, C.E., Phelps, R.H., Pollard, G.V., Khambay, B.P.S., 1999. Screening of medicinal plants from Trinidad and Tobago for antimicrobial and insecticidal properties. J. Ethnopharmacol. 64, 265-270.
|
Larvicide |
Growth of Aedes aegypti larvae |
Ethyl acetate and petroleum ether fraction |
0.5 mg/ml |
Toxicity to larvae in stage IV of development |
Chariandy et al. (1999)Chariandy, C.M., Seaforth, C.E., Phelps, R.H., Pollard, G.V., Khambay, B.P.S., 1999. Screening of medicinal plants from Trinidad and Tobago for antimicrobial and insecticidal properties. J. Ethnopharmacol. 64, 265-270.
|