Acta Cirurgica Brasileira
On-line version ISSN 1678-2674
SANTOS, Edivar Pereira dos; ROCHA, Ademir; MENEGHINI, Alexandre João and SILVA, Alcino Lázaro da. Effect of the pleuroperitoneal derivation in the treatment of induced recurrent hydrothorax: pleurodese in rabbits. Acta Cir. Bras. [online]. 2003, vol.18, n.1, pp. 01-12. ISSN 1678-2674. http://dx.doi.org/10.1590/S0102-86502003000100007.
PURPOSE: In order to determine the pleurodese, after-got of tetracycline injection, the pleuroperitoneal in the treatment of induced recurrent hydrothorax in rabbits. METHODS: Thirty male and adult New-Zealand rabbits were used. It was used dissociated anesthesia quetamina and xylazine association, (0,1 cm3 per 100g animal weight) by intramuscular injection.. In order to induce hydrothorax, 7 mg/kg of tetracycline diluted in 10 cm3 distilled water (pH 4) was percutaneous injected, in the 4th left anterior intercostal space with 25.6 mm diameter needle. The surgical procedure was a 4 cm long down rib laparatomy on the left, and a 0,5 cm diameter hemidiaphragm incision in the venter musculi; in group A, it was closure of the diaphragm opening with a single monofilament suture; in the group B, after the opening of the diaphragm, it was introduced a 2 cm long cylindrical prothesis, politetrafluor etileno (PTFE), Atrium Medical Corporation, number 3; in the group C, the surgical procedure was a 2 cm long down rib laparotomy on the left and toracotomy a 2,5 cm long on the left, and than it was introduced a catheter number 6 French (IBRAS-CBO) on the pleurointercostodermoperitoneal way. In the post operatory, it was carried out the induced and repeated hydrothorax on the 1st, 5th, 8th, and 12th days, in all groups of study, using 7 mg/kg intrapleural injection of tetracycline (pH 4,0) in the 4th left anterior intercostal space. Euthanasia took place on the 15th post operatory day, and necropsia in order to remove pleural effusion and do histological study of pleura, lung and parietal peritoneum. RESULTS: The pleural effusion resultant was more significant on group A. The pleurodese resultant index was 100% on group B, and 80% on group C. CONCLUSIONS: The pleuroperitoneal derivation get advantage pleurodese histologic testable, again with tetracycline little dose in rabbits.
Keywords : Pleura; Recurrent hydrothorax; Pleuroperitoneal derivation; Pleurodese.