SciELO - Scientific Electronic Library Online

vol.18 suppl.5Prevalence and bacterial susceptibility of hospital acquired urinary tract infectionLaparoscopic adrenalectomy: analysis of 11 pacients author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Acta Cirurgica Brasileira

Print version ISSN 0102-8650On-line version ISSN 1678-2674


FERNANDES, Luis Pinto et al. Behavior of cholinesterase and liver mitochondrial function in dogs submitted to normothermic ischemia and reperfusion. Acta Cir. Bras. [online]. 2003, vol.18, suppl.5, pp.38-41. ISSN 0102-8650.

PURPOSE: The plasmatic activity of the cholinesterase (CHE) and the liver mitochondrial function, expressed by the ratio of respiratory control (RCR), were studied during normothermic ischemia. METHODS: Sixteen adult mongrels, eight females and eight males were submitted to ischemia by clamping of the hepatic artery, portal vein and infrahepatic inferior vena cava, infra-hepatic, for two h, follwed by reperfusion for 1 h. The CHE and the mitochondrial function were evaluated at 60 and 120 min. of ischemia and at 15 and 60 minutes of reperfusion. RESULTS: The CHE decreased, significantly, during ischemia and in reperfusion. The RCR was decreased at 120 min. of ischemia, returning to the initial values on reperfusion. CONCLUSION: In this study, the CHE was a sensitive indicator of ischemic injury , suggesting irreversibility of ischemia injury. The RCR, by other side, showed a greater sensibility than the CHE in detection sense, during the studied period, the reversibility of the hepatic ischemic injury.

Keywords : Cholinesterase; Mitochondral function; Passive venous bypass; Liver transplantation; Ischemia; Reperfusion.

        · abstract in Portuguese     · text in English     · English ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License