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Acta Cirurgica Brasileira

Print version ISSN 0102-8650On-line version ISSN 1678-2674


KUCZYNSKI, Lauro Bogodar; SPADELLA, César Tadeu  and  PADOVANNI, Carlos Roberto. Endocrine and exocrine consequences of the open and ligated pancreatic duct: clinical and laboratorial findings in rabbits. Acta Cir. Bras. [online]. 2004, vol.19, n.3, pp.238-262. ISSN 0102-8650.

After pancreatic ressections due to chronic pancreatitis the remnant pancreas can lead to new outbreaks of pancreatitis in variable degrees of severity. After the resections by tumors or pancreatitis, the most common complications are the pancreatic fistulas with their resultant morbidity and mortality. In the pancreas transplantation the bowel or bladder drainage of the exocrine part of the graft, beyond the technical peculiarities of the execution, is not exempt of several complications. In order to avoid or reduce such consequences and trying to simplify the surgical technique, there have been used other approaches for the treatment of the pancreatic stump/graft: free drainage of the secretions with the duct left open, ductal ligature and duct occlusion with polymers. PURPOSE: The proposal of our investigation was to study the clinical and laboratorial effects of the ductal ligature and the ductal left open in the endocrine and exocrine compounds of the rabbit pancreas. METHODS: One hundred and fifty operations were performed, divided in 3 groups: laparotomy/control (n=50), opened group (n=50) and ligated (n=50). The moments of observation were pre-operative, day 0 (operation's day) and post-operative (observation and sacrifice): 7 days, 14 days, 28 days, 90 days and 180 days. The parameters analysed were: general clinic state, activity and controls of body weight, water intake, food intake and measurements of blood and urinary glucose, serum-amylase and plasma insulin levels. RESULTS: All the groups had a similar clinical evolution: progressive body weight gain, water and food intake, as well as in good health conditions. CONCLUSIONS: Except for a significant serum-amylase elevation in the first 24-48 hours for the two ductal interference groups, there were no other blood glucose and insulin and urine-glucose variations in the 3 groups, in all observation moments.

Keywords : Pancreas; Pancreas ductal ligature; Duct left open; Peritoneum.

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