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Acta Cirurgica Brasileira

Print version ISSN 0102-8650On-line version ISSN 1678-2674


ORTOLAN, Erika Veruska Paiva; SPADELLA, César Tadeu; MACHADO, José Lúcio Martins  and  KOBAYASI, Shoiti. The evaluation of healing parameters in the colon of diabetic rats without surgical injury. Acta Cir. Bras. [online]. 2004, vol.19, n.3, pp.286-295. ISSN 0102-8650.

PURPOSE: There are few studies using healing parameters in diabetic animals before the wound, and no studies in the colon. The aim of this study was to verify if alloxan diabetes-induced could primarily change parameters commonly used to measure the small bowel healing in surgical wounded rats, although using animals without any surgical procedure. METHODS: 180 rats were assigned to in two groups, of non-diabetic control animals, and diabetic animals. The animals were considered diabetics if blood glucose level>200mg/dl and urinary glucose level>3000mg/dl. After 3 months, both groups were evaluated in 6 moments of sacrifice, when were analyzed diabetes (blood and urinary glucose levels and plasmatic insulin) and healing in the colon (breaking strength, hydroxyproline, total tissue protein and the ratio OHP/TTP). RESULTS: Alloxan 2% caused 42,3% of mortality and 72,4% of severe diabetes. All animals in the diabetic group (G2) presented with blood glucose>300mg/dl and urinary glucose>3000mg/dl and significant decrease in plasmatic insulin. Neither the breaking strength, nor the biochemical dosages (HOP, TTP) showed up any meaningful statistical variation between groups. CONCLUSION: The findings of our study suggest that diabetes by itself is not able to change healing parameters, before the surgical injury in the colon of rats.

Keywords : Experimental diabetes mellitus; Healing; Colon.

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