Acta Cirurgica Brasileira
On-line version ISSN 1678-2674
PICCINATO, Carlos Eli; DE DOMENICO JR, Armando; JORDAO JR, Alceu Afonso and VANNUCCHI, Helio. Skeletal muscle ischemia and reperfusion in rats increase lipid peroxidation in rats. Acta Cir. Bras. [online]. 2004, vol.19, n.5, pp.578-581. ISSN 1678-2674. http://dx.doi.org/10.1590/S0102-86502004000500018.
PURPOSE: To determine the effects of 30 minutes of ischemia followed by 30 minutes of reperfusion in skeletal muscle of rats receiving three different diets (supplemented, normal and vitamin E deficient) on lipoperoxidation (LP). METHODS: LP measured by TBARS levels, and plasma and hepatic concentrations of vitamin E measured by HPLC. RESULTS: The deficient group presented higher lipoperoxidation levels in muscle compared to the control and supplemented groups. CONCLUSION: Supplementation with vitamin E decrease the free radicals production in ischemia/reperfusion in skeletal muscle of rats.
Keywords : Ischemia; Skeletal muscle; Vitamin E; Free radicals; Rats.