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Acta Cirurgica Brasileira

Print version ISSN 0102-8650On-line version ISSN 1678-2674


PICCINATO, Carlos Eli; DE DOMENICO JR, Armando; JORDAO JR, Alceu Afonso  and  VANNUCCHI, Helio. Skeletal muscle ischemia and reperfusion in rats increase lipid peroxidation in rats. Acta Cir. Bras. [online]. 2004, vol.19, n.5, pp.578-581. ISSN 0102-8650.

PURPOSE: To determine the effects of 30 minutes of ischemia followed by 30 minutes of reperfusion in skeletal muscle of rats receiving three different diets (supplemented, normal and vitamin E deficient) on lipoperoxidation (LP). METHODS: LP measured by TBARS levels, and plasma and hepatic concentrations of vitamin E measured by HPLC. RESULTS: The deficient group presented higher lipoperoxidation levels in muscle compared to the control and supplemented groups. CONCLUSION: Supplementation with vitamin E decrease the free radicals production in ischemia/reperfusion in skeletal muscle of rats.

Keywords : Ischemia; Skeletal muscle; Vitamin E; Free radicals; Rats.

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