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Acta Cirurgica Brasileira

Print version ISSN 0102-8650On-line version ISSN 1678-2674


SASSIOTO, Maria Cristina Pita et al. Effect of Casearia sylvestris on bone repair with devitalized bovine bone matrix in rats. Acta Cir. Bras. [online]. 2004, vol.19, n.6, pp.637-641. ISSN 0102-8650.

Purpose: To evaluate the use of devitalized bovine bone matrix with Casearia sylvestris decoct treatment to regenerate femoral defect in rats. Methods: Twenty-four adult male Wistar rats were used in this study. Bilateral femoral defects with 2mm diameter were surgically produced and fulfilled with particulate inorganic bovine bone. Casearia sylvestris decoct treatment was realized in the preoperative period. The animals were sacrificed 10, 20 and 30 postoperative days and specimens were submitted to histomorphometric evaluation. The data was submitted a statistical evaluation with Student t-test. Results: The bone formation was reduced in the experimental animals at 10 (p = 0,0000), 20 (p = 0,0049) and 30 (p = 0,0003) postoperative days. Conclusion: The association of Casearia sylvestris decoct treatment and the fulfillment of defect with particulate inorganic bovine bone seemed to decrease bone formation.

Keywords : Bone and Bones; Rats.

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