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Acta Cirurgica Brasileira

Print version ISSN 0102-8650On-line version ISSN 1678-2674

Abstract

PEREIRA, Maria Ligia Lyra et al. Hiperbaric oxygen in actinic lesions of rat colon: morphological and morphometric aspects. Acta Cir. Bras. [online]. 2004, vol.19, n.6, pp.658-663. ISSN 0102-8650.  http://dx.doi.org/10.1590/S0102-86502004000600013.

Purpose: To evaluate the effects of hiperbaric oxygen on the radiation-induced actinic lesions in the rat distal colon. Methods: Thirty-two Wistar female rats were divided into four groups: I - sham; II - hiperbaric oxygen therapy (HOT); III - radiotherapy (RT), e IV - radiotherapy and hiperbaric oxygen (the same manner of II and III group). Fragments of distal colon were fixed into 10% formadehyde and proceeded for the histological routine and morphology. Results: The experimental results showed the intestinal gland lesions, vasodilation and infiltrated leucocytes in propria laminae and submucosae in rat colon of GIII that accentuated colon after hiperbaric oxygen Conclusion: Hiperbaric oxygen attenuated the morphological changes in the mucosae and submucosae of the rat distal colon with radiation-induced inflammatory process.

Keywords : Hyperbaric Oxygenation; Radiotherapy; Colon; Rats.

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