SciELO - Scientific Electronic Library Online

 
vol.19 issue6Respiratory repercussion of pneumoperitoneum induced in pigsEffect of acetylsalicylic acid and acetic acid solutions in liver of rabbits author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Acta Cirurgica Brasileira

Print version ISSN 0102-8650On-line version ISSN 1678-2674

Abstract

GRECA, Fernando Hintz et al. The use of porcine small intestine submucosa as a graft for urinary bladder augmentation in dogs. Acta Cir. Bras. [online]. 2004, vol.19, n.6, pp.670-676. ISSN 0102-8650.  http://dx.doi.org/10.1590/S0102-86502004000600015.

Purpose: To evaluate the biocompability and histological changes of the porcine intestine submucosa (SIS) used for bladder augmentation in dogs. Methods: eight mongrel dogs underwent laparotomy and a 3cm full-thickness midline cistotomy was performed in its ventral surface. In order to produce an immediate augmentation of the bladder, a porcine SIS patch graft was implanted. On the 30th post-operative day the animals were submitted to a second operation for a grossly evaluation of the implanted graft. Results: there was no finding of seroma, hematoma, abscess, fistula, adhesion and stone formation. The bladder was then removed for histological studies and the animals were sacrificed. A chronic inflammatory process was observed in all animals. The urothelium covered the implant in 100% of the cases and smooth muscles fibers were seen in the graft area. The angiogenesis was significant and reabsorption of the implanted submucosa could be observed. The densitometry of collagen showed that the area occupied by immature collagen type III was greater than the area occupied by the mature collagen, type I. Conclusion: SIS can be used as a bladder substitute, since it acts as a scaffold for tissue regeneration.

Keywords : Intestine, Small; Surgical Flaps; Bioprosthesis; Bladder; Dogs.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf epdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License