Abstract

SAAD-HOSSNE, Rogério; PRADO, René Gamberini  and  HOSSNE, William Saad. Effect of acetylsalicylic acid and acetic acid solutions in liver of rabbits. Acta Cir. Bras. [online]. 2004, vol.19, n.6, pp. 677-686. ISSN 1678-2674.  http://dx.doi.org/10.1590/S0102-86502004000600016.

Purpose: In the present work, 2.5% and 5% acetyl salicylic acid solution and acetic acid solutions were tested in vivo. Methods: In all tests control animals were used and given salt solution. 80 male rabbits were employed and randomly distributed among the different experimental groups. Results: When injected in the liver of healthy rabbits (in vivo), both solutions produced localized destruction (coagulative necrosis) of the hepatic parenchyma in 24 hours. After 14 days, these lesions either disappeared or were replaced by mild scars (fibrosis). The lesions were not followed by clinical alterations and the only observed biochemical alteration was an increase in the amount of alanine amino transferase after 24 hours. Conclusion: In vivo, the effects of both concentrations (2.5% and 5%) were the same, although more intense at 5%. The experimental results support the eventual clinical application of the acetyl salicylic acid solution and acetic acid solution in the treatment of liver metastases.

Keywords : Carcinoma; Aspirin; Acetic Acid; Liver; In vitro; Rabbits.