SciELO - Scientific Electronic Library Online

vol.20 issue4Histamine combined with melphalan in isolated limb perfusion for the treatment of locally advanced soft tissue sarcomas: preclinical studies in ratsClinical and histopathological study of tissue reactivity to monofilament suture materials: nylon and poliglecaprone 25 in rats author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Acta Cirurgica Brasileira

Print version ISSN 0102-8650On-line version ISSN 1678-2674


TENORIO, Angélica da Silva et al. Effect of physical training on the bone tissue and the calcium serum concentration in ovariectomized mice. Acta Cir. Bras. [online]. 2005, vol.20, n.4, pp.280-283. ISSN 0102-8650.

PURPOSE: The aim of this study is to evaluate possible morphometric alterations in bone tissue and the calcium serum concentration in ovariectomized mice subjected to physical training. METHODS: Fifty female mice, aged 90 days, divided into 5 groups (n=10): control (C), pseudo-operated sedentary (POS), pseudo-operated trained (POT), ovariectomized sedentary (OVS) and ovariectomized trained (OVT). Groups OVS and OVT were subjected to an ovariectomy, and groups POS and POT were subjected to a pseudo-surgery. Thirty days after the surgery, groups POT and OVT were subjected to physical training during 05 weeks in ergometer at a speed of 20m/min. The other animals stayed sedentary at the same period. Afterwards the animals were sacrificed and had blood collected to realize calcium serum dosage and the rigth femurs were collected to realize a histomorphometric study. RESULTS: The calcium serum concentration in group OVT was lower than the other groups (p<0,05). The mass of femurs in groups POT and OVT was higher than the group Control (p<0,05). The average density of the osteocytes was higher in group OVS (p<0,05). The average value of the area of the osteocytes showed difference only between groups POS and OVS (p<0,05). There were no differences in the bone length, nor in the osteocytes perimeter. CONCLUSION: The physical training in part prevented the alterations in the bone tissue due to the ovariectomy and enabled an increase of the bone formation.

Keywords : Bone metabolism; Physical training; Ovariectomy.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License