Abstract

MENEZES, Honório Sampaio et al. Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test. Acta Cir. Bras. [online]. 2008, vol.23, n.5, pp. 447-450. ISSN 1678-2674.  http://dx.doi.org/10.1590/S0102-86502008000500010.

PURPOSE: To compare the effects of the antidepressant drugs duloxetine and amitriptyline on depressive behaviors in rats. METHODS: Fifteen male Wistar rats were given systemic injections of duloxetine, amitriptyline or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. Data were analyzed by one-way ANOVA and Kruskall-Wallis. RESULTS: Rats given injections of duloxetine displayed fewer stops than the amitriptyline and control group (p< 0.05). The control group and Amitriptyline showed no difference (p=0.8). CONCLUSION: Duloxetine reduced depressive behaviors in the Forced Swimming Test been more effective than amitriptyline.

Keywords : Physiological Effects of Drugs; Depression; Animal Experimentation; Rats.