SciELO - Scientific Electronic Library Online

 
vol.26 número3Topical hepatic hypothermia plus ischemic preconditioning: analysis of bile flow and ischemic injuries after initial reperfusion in ratsAnesthetic recovery and hemodynamic effects of continuous thiopental infusion versus halothane for maintenance anesthesia in patients undergoing ocular surgery índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Acta Cirurgica Brasileira

versión On-line ISSN 1678-2674

Resumen

CURTIS, Fabio Geraldo et al. Dexmedetomidine and S(+)-ketamine in ischemia and reperfusion injury in the rat kidney. Acta Cir. Bras. [online]. 2011, vol.26, n.3, pp. 202-206. ISSN 1678-2674.  http://dx.doi.org/10.1590/S0102-86502011000300008.

PURPOSE: To investigate blood creatinine and renal histology in rats anesthetized with S(+)-ketamine (keta) or dexmedetomidine (dex) and submitted to kidney ischemia/reperfusion injury (IRI). METHODS: Under intraperitoneal (ip) S(+)-ketamine, 20 male Wistar rats were divided into two groups (n=10): maintenance with iv S(+)-ketamine or dex (keta and dex groups), and submitted to right (R) nephrectomy and left (L) renal artery clamping for 45 min. Blood creatinine was measured before ischemia (T1) and 48h after reperfusion (T2), when L nephrectomy was performed. Histological analysis was performed in all kidneys. RESULTS: Blood creatinine was significantly higher at T2 in both groups, but dex group results were lower than those of keta group. Histological changes: between groups, R kidneys did not differ; there were significant high scores for vascular dilation: keta L kidneys; for vascular congestion, tubular dilation, and necrosis: L kidneys from both groups; for tubular degeneration: keta R kidneys. CONCLUSION: S(+)-ketamine plus IRI were aggressive to rat kidneys, according to histological changes, and dexmedetomidine may have not totally protected the kidneys from these injuries, despite the better results of blood creatinine.

Palabras llave : Dexmedetomidine; Kidney; Reperfusion Injury; Creatinine; Necrosis; Rats.

        · resumen en Portugués     · texto en Inglés     · pdf en Inglés