Resumen

ALBERTI, Luiz Ronaldo; VASCONCELLOS, Leonardo de Souza  y  PETROIANU, Andy. Influence of local or systemic corticosteroids on skin wound healing resistance. Acta Cir. Bras. [online]. 2012, vol.27, n.4, pp. 295-299. ISSN 1678-2674.  http://dx.doi.org/10.1590/S0102-86502012000400003.

PURPOSE: To compare the resistance of skin wound healing of mice submitted to local or systemic hydrocortisone administration, in different postoperative periods. METHODS: An incision and suture was performed on the thoracic skin of 130 male mice: Group 1 (n = 10) resistance of the integer skin; Group 2 (n = 30) submitted only to skin incision and suture; Group 3 (n = 30) skin incision and suture followed by administration of saline fluid; Group 4 (n = 30) skin incision and suture followed by administration of local hydrocortisone; Group 5 (n = 30) skin incision and suture followed by administration of systemic hydrocortisone. The resistance of the wound healing and the weight of the animals were studied on the seventh, 14^th and 21^st postoperative days. Histological examination was also performed. RESULTS: The mice that received corticoid (groups 4 and 5) presented significant decreasing on their weight (p = 0.02). The Groups 3, 4 and 5 showed lower scar resistance than Group 2 on the seventh postoperative day (p < 0.05). On the 14^th and 21^st days, there was no difference on the skin would healing resistance (p > 0.05). CONCLUSION: Administration of hydrocortisone in mice is responsible for weight decreasing and reduction of the skin wound healing resistance during the first postoperative week.

Palabras llave : Hydrocortisone [administration & dosage]; Adrenal Cortex Hormones [administration and dosage]; Wound Healing [drug effects]; Models, Biological; Mice.